Publication
PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerMalignant Breast Neoplasmcivic_curation1.00
- drugTamoxifencivic_curation1.00
- genePIK3CAcivic_curation1.00
- variantPIK3CA Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 17575221
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PIK3CA H1047R1 | ||||||||
| Trastuzumab | Malignant Breast Neoplasm | Predictive | B | Supports Resistance | — | submitted | EID2101In unilateral breast cancer patients, PIK3CA mutation was associated with improved local recurrence-free survival. PMID 17575221 · Pérez-Tenorio et al., 2007 · Open in CIViC | civic |
| PIK3CA Mutation2 | ||||||||
| (prognostic) | Malignant Breast Neoplasm | Prognostic | B | Supports Better Outcome | 3 | accepted | EID6188This was a Swedish study of 270 breast tumors removed from patients with unilateral operable breast cancer, and either lymph node metastases or a tumor diameter >30mm. PIK3CA missense mutations were f… (full text at CIViC) PMID 17575221 · Pérez-Tenorio et al., 2007 · Open in CIViC | civic |
| Tamoxifen | Estrogen Receptor-positive Breast CancerUNRESOLVED | Predictive | B | Does Not Support Sensitivity Response | 3 | accepted | EID6189This was a Swedish study of 270 breast tumors removed from patients with unilateral operable breast cancer, and either lymph node metastases or a tumor diameter >30mm. PIK3CA missense mutations were f… (full text at CIViC) PMID 17575221 · Pérez-Tenorio et al., 2007 · Open in CIViC | civic |