Publication
Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2B.
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Cancer Res2006PMID 17108110stubpubmedProvenance
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- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
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civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
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- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 17108110
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| RET M918T1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 5 | accepted | EID12805RET is a known oncogene that encodes a receptor tyrosine kinase with important roles in cell growth, differentiation, and survival. Germline M918T is strongly linked with multiple endocrine neoplasia … (full text at CIViC) PMID 17108110 · Gujral et al., 2006 · Open in CIViC | civic |