Publication
Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (2)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 2
- geneFGFR3civic_curation1.00
- variantFGFR3 G380Rcivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 16841094
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FGFR3 G370C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 2 | rejected | EID104141 patient's biopsy, which was the common soft subtype of keratinocytic epidermal nevi, displayed a double mutation of both FGFR3 G372C and G382R. The nevus from which the biopsy was taken displayed no… (full text at CIViC) PMID 16841094 · Hafner et al., 2006 · Open in CIViC | civic |
| FGFR3 G380R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 1 | accepted | EID10415A patient's biopsy, which was the common soft subtype of keratinocytic epidermal nevi, displayed a double mutation of both FGFR3 G372C (aka G370C) and G382R (aka G380R). The nevus from which the biops… (full text at CIViC) PMID 16841094 · Hafner et al., 2006 · Open in CIViC | civic |
| FGFR3 R248C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 3 | submitted | EID1041339 common nonepidermolytic, nonorganoid keratinocyte epidermal nevi were sampled from 33 patients and analyzed using a SNaPshot assay. FGFR3 R248C was found in 15/39 samples and 9/33 patients. The two… (full text at CIViC) PMID 16841094 · Hafner et al., 2006 · Open in CIViC | civic |