Publication
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerKidney Carcinomacivic_curation1.00
- drugTemsirolimuscivic_curation1.00
- geneVHLcivic_curation1.00
- variantVHL Losscivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 16341243
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| VHL Loss1 | ||||||||
| Temsirolimus | Kidney CarcinomaALIAS | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1035Preclinical studies linking the efficacy of mTOR inhibitor CCI-779 to VHL loss in vitro and in mouse models of kidney cancer. VHL-deficient tumors were more sensitive to mTOR inhibition than VHL-profi… (full text at CIViC) PMID 16341243 · Thomas et al., 2006 · Open in CIViC | civic |
| VHL Loss-of-function1 | ||||||||
| Temsirolimus | Renal Cell CarcinomaCURATED_BROADER | Predictive | D | Supports Sensitivity Response | 3 | submitted | EID4828A preclinical study to show sensitization to mTOR inhibition with Temsirolimus in renal cell carcinoma cells and a mouse mode showing a VHL loss of function. Growth arrest caused by Temsirolimus corr… (full text at CIViC) PMID 16341243 · Thomas et al., 2006 · Open in CIViC | civic |