Publication
Oncogenic properties of the mutated forms of fibroblast growth factor receptor 3b.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerBladder Urothelial Carcinomacivic_curation1.00
- cancerMalignant Bladder Neoplasmcivic_curation1.00
- geneFGFR3civic_curation1.00
- variantFGFR3 S249Ccivic_curation1.00
- variantFGFR3 Y373Ccivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 16338952
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FGFR3 S249C1 | ||||||||
| (oncogenic) | Bladder Urothelial Carcinoma | Oncogenic | D | Supports Oncogenicity | 4 | accepted | EID8853In contrast to controls (empty vector and FGFR3 wild-type overexpression NIH-3T3 cell lines), the stable transfection of NIH-3T3 cells with FGFR3b-S249C led to ligand-independent phosphorylation of FG… (full text at CIViC) PMID 16338952 · Bernard-Pierrot et al., 2006 · Open in CIViC | civic |
| FGFR3 Y373C1 | ||||||||
| (oncogenic) | Malignant Bladder NeoplasmALIAS | Oncogenic | D | Supports Oncogenicity | 3 | accepted | EID8881The authors identified a bladder cancer cell line (MGH-U3) with a homozygous Y373C mutation. With immunoprecipitation (IP), and immunoblotting (IB) experiments, they demonstrated constitutional phosph… (full text at CIViC) PMID 16338952 · Bernard-Pierrot et al., 2006 · Open in CIViC | civic |