Publication
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (9)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 9
- cancerAcute Myeloid Leukemiacivic_curation1.00
- cancerAcute Myeloid Leukemia with NPM1 Mutationcivic_curation1.00
- drugCytarabinecivic_curation1.00
- drugDaunorubicincivic_curation1.00
- drugEtoposidecivic_curation1.00
- geneNPM1civic_curation1.00
- variantNPM1 EXON 11 MUTATIONcivic_curation1.00
- variantNPM1 MUTATIONcivic_curation1.00
- variantNPM1 W288FScivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 15659725
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| NPM1 EXON 11 MUTATION1 | ||||||||
| (prognostic) | Acute Myeloid LeukemiaCURATED_BROADER | Prognostic | B | Supports Better Outcome | 3 | accepted | EID177Cytoplasmic localization of NPM in AML patients was an independent prognositic factor associated with complete remission in response to induction therapy in a multivariate analysis (p=0.019) but not i… (full text at CIViC) PMID 15659725 · Falini et al., 2005 · Open in CIViC | civic |
| NPM1 W288FS1 | ||||||||
| Cytarabine + Daunorubicin + EtoposideCombination | Acute Myeloid LeukemiaCURATED_BROADER | Predictive | E | Supports Sensitivity Response | 3 | accepted | EID153NPM1 mutation (Type A, W288fs) causes cytoplasmic localization of NPM when transfected into a non-hematopoietic cell line (293T cells). Cytoplasmic localization of NPM in AML patients was associated w… (full text at CIViC) PMID 15659725 · Falini et al., 2005 · Open in CIViC | civic |
| NPM1 MUTATION1 | ||||||||
| (diagnostic) | Acute Myeloid Leukemia with NPM1 MutationALIAS | Diagnostic | B | Supports Positive | 4 | accepted | EID12494In this 2005 study, immunohistochemical staining was used to assess the subcellular localization of NPM in 1,835 paraffin-embedded tumor specimens, including 591 from primary AML patients (ages 15–60)… (full text at CIViC) PMID 15659725 · Falini et al., 2005 · Open in CIViC | civic |