Publication
Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome.
Authors not recorded
Cancer Res2003PMID 12517791stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerProstate Carcinomacivic_curation1.00
- drugBicalutamidecivic_curation1.00
- geneARcivic_curation1.00
- variantAR W742civic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 12517791
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| AR W7421 | ||||||||
| Bicalutamide | Prostate Carcinoma | Predictive | D | Supports Resistance | 4 | accepted | EID448LNCaP-FGC cells with mutations at codon 741 (W741C, W741L) were able to use bicalutamide as an AR agonist, promoting cell growth and increased prostate-specific antigen secretion. PMID 12517791 · Hara et al., 2003 · Open in CIViC | civic |