Publication
Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerBreast Secretory Carcinomacivic_curation1.00
- geneNTRK3civic_curation1.00
- variantNTRK3 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 12450792
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| NTRK3 Fusion3 | ||||||||
| (diagnostic) | Breast Secretory Carcinoma | Diagnostic | B | Supports Positive | 3 | submitted | EID10503A 6-year-old female had invasive breast adenocarcinoma with the histopathologic features of a secretory breast carcinoma (SBC). FISH and RT-PCR on frozen tumor tissue found ETV6::NTRK3 fusion. 11 of … (full text at CIViC) PMID 12450792 · Tognon et al., 2002 · Open in CIViC | civic |
| 〃 | Breast Secretory Carcinoma | Diagnostic | B | Supports Positive | 3 | accepted | EID1134412 of 13 (92%) secretory breast carcinomas were found to have ETV6::NTRK3 fusions by RT-PCR and/or FISH whereas other infiltrating ductal carcinomas were negative for the fusion. PMID 12450792 · Tognon et al., 2002 · Open in CIViC | civic |
| (oncogenic) | Breast Secretory Carcinoma | Oncogenic | D | Supports Oncogenicity | 3 | accepted | EID10504A 6-year-old female was diagnosed with secretory breast carcinoma (SBC), a rare invasive breast adenocarcinoma. Analysis of the tumor revealed a genetic driver: an ETV6::NTRK3 gene fusion. This fusion… (full text at CIViC) PMID 12450792 · Tognon et al., 2002 · Open in CIViC | civic |