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Retinal hemangioblastoma in von Hippel-Lindau disease: a clinical and molecular study.

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Invest Ophthalmol Vis Sci2002PMID 12202531stubpubmedProvenance
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PubMed
Retrieved
Sep 8, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-CIVIC-20260908-000001
Published

Abstract

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Linked entities

Linked entities (17)

How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.

Validated 17

Curated evidence

Evidence citing this paper (53)

50 items per page.

civicProvenance
Source
CIViC — Clinical Interpretation of Variants in Cancer
Dataset
CIViC evidence items
Version
civic-2026-09-08
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Evidence
expert curation
License
CC0 1.0
PMID
12202531
Run
ING-CIVIC-20260908-000001
Open at source
CuratedShowing 1–50 of 53 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.
TherapyCancerTypeLevelDirection · significanceRating (1–5)StatusEvidenceSource
VHL A149fs (c.444dup)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9982

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL C162W (c.486C>G)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9990

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL E46* (c.136G>T)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition4accepted
EID4895

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL E52K (c.154G>A)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition4accepted
EID4896

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations revealed that the number of hemangioblastomas appeared higher in patients who had a substitu… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL E55fs (c.163dupG)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition3submitted
EID9966

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL F136S (c.407T>C)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition3submitted
EID9997

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL F76del (c.227_229del)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition3submitted
EID9995

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL G104A (c.311G>C)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition4accepted
EID5512

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL G114R (c.340G>C)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9973

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL H115Q (c.345C>G)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition4accepted
EID5515

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL H115Y (c.343C>T)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9975

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL H191FS (c.571delC)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9983

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL K159fs (c.473dup)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9986

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL L118P (c.353T>C)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9976

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL L140fs (c.417_418delTC)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9972

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL L158P (c.473T>C)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition3accepted
EID9537

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations revealed that the number of hemangioblastomas appeared higher in patients who had a substitu… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL L188P (c.563T>C)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9981

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL N67_V74del (c.197_220del)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition3submitted
EID9968

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL N78S (c.233A>G)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition3accepted
EID9539

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations revealed that the number of hemangioblastomas appeared higher in patients who had a substitu… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL P154= (c.462A>C)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9979

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL P71fs (c.211insT)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition3submitted
EID9969

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL P86S (c.256C>T)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID10000

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL Q132P (c.395A>C)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9977

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL Q203fs (c.607_608delCA)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9984

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL Q73* (c.217C>T)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition3submitted
EID9999

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL Q96* (c.286C>T)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID10001

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL R107H (c.320G>A)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition4accepted
EID5513

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL R108fs (c.322_323insTG)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition2submitted
EID9970

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL R113* (c.337C>T)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition3accepted
EID9541

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations revealed that the number of hemangioblastomas appeared higher in patients who had a substitu… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL R161* (c.481C>T)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition3accepted
EID9540

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations revealed that the number of hemangioblastomas appeared higher in patients who had a substitu… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL R161Q (c.482G>A)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9991

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL R167Q (c.500G>A)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition3accepted
EID9538

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations revealed that the number of hemangioblastomas appeared higher in patients who had a substitu… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL R167W (c.499C>T)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9988

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL R205fs (c.614_615delGC)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9985

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL R82P (c.245G>C)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition4accepted
EID5511

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL Rearrangement1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9987

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL S111C (c.331A>T)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition4accepted
EID5514

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL S65P (c.193T>C)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition4submitted
EID5509

Study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations revealed that the number of hemangioblastomas appeared higher in patients who had a substituti… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL S80N (c.239G>A)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition3submitted
EID9996

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL S80R (c.238A>C)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition4accepted
EID5510

Study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations revealed that the number of hemangioblastomas appeared higher in patients who had a substituti… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL Splice Site (c.340+1G>A)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9974

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL T105P (c.313A>C)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID10003

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL V130L (c.388G>C)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID10002

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL V130Wfs*30 (c.385_386dup)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9971

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL V155L (c.463G>C)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition4accepted
EID5516

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL V166F (c.496G>T)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID9989

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL V62fs (c.180delG)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition3submitted
EID9967

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL W117C (c.351G>T)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCN/A N/A3submitted
EID10004

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL Y156* (c.468T>G)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition3submitted
EID9994

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic
VHL Y156C (c.467A>G)1
(predisposing)Von Hippel-Lindau DiseaseUNRESOLVEDPredisposingCSupports Predisposition3submitted
EID9998

A study of 103 patients with VHL retinal manifestations and 108 patients without VHL retinal manifestations extracted from the French VHL database revealed that the number of hemangioblastomas appeare… (full text at CIViC)

PMID 12202531 · Dollfus et al., 2002 · Open in CIViC

civic