Publication

Differential activation of cysteine-substitution mutants of fibroblast growth factor receptor 3 is determined by cysteine localization.

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J Bone Miner Res2002PMID 12009017stubpubmedPublished

Abstract

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Linked entities

Linked entities (2)

How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.

Validated 2

geneFGFR3civic_curation1.00
variantFGFR3 Y373Ccivic_curation1.00

Curated evidence

Evidence citing this paper (3)

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
FGFR3 Fusion1
(diagnostic)	Thanatophoric DysplasiaUNRESOLVED	Diagnostic	B	Supports Positive	3	submitted	EID7224 Various human skeletal disorders are thought to be caused by mutations in fibroblast growth factor receptor 3 (FGFR3). These result in chronic FGFR3 hyperactivation and inhibition of bone growth. One … (full text at CIViC) PMID 12009017 · Adar et al., 2002 · Open in CIViC	civic
FGFR3 G370C1
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	2	submitted	EID13141 FGFR3 G370C was functionally evaluated in 293T, L8, and RCJ cells using chemical cross-linking, Western blotting, and c-fos luciferase assays. Compared with WT FGFR3, G370C demonstrated spontaneous li… (full text at CIViC) PMID 12009017 · Adar et al., 2002 · Open in CIViC	civic
FGFR3 Y373C1
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	3	accepted	EID13201 FGFR3 Y373C expressed in 293T cells shows ligand-independent dimerization and increased autophosphorylation compared to wild type FGFR3. PMID 12009017 · Adar et al., 2002 · Open in CIViC	civic