Publication
Overexpression of pRB in human pancreatic carcinoma cells: function in chemotherapy-induced apoptosis.
Authors not recorded
J Natl Cancer Inst2002PMID 11792751stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (7)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 7
- cancerPancreatic Adenocarcinomacivic_curation1.00
- drugDoxorubicincivic_curation1.00
- drugFluorouracilcivic_curation1.00
- drugGemcitabinecivic_curation1.00
- drugMitomycincivic_curation1.00
- geneRB1civic_curation1.00
- variantRB1 Overexpressioncivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 11792751
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| RB1 Overexpression1 | ||||||||
| Doxorubicin + Fluorouracil + Gemcitabine + MitomycinSubstitutes | Pancreatic Adenocarcinoma | Predictive | D | Supports Resistance | 2 | accepted | EID1324In Capan-1 cell lines engineered to reduce pRB expression (by transfection with p16), resensitization to chemotherapy-induced apoptosis was observed. The effect was asserted to be specific to pRB depl… (full text at CIViC) PMID 11792751 · Plath et al., 2002 · Open in CIViC | civic |