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Derived
For each drug, the most advanced stage supported by registered interventional trials and jurisdiction-aware approval records. Approval in any ingested jurisdiction outranks trial phase; a drug is counted once, at its highest stage.
Computedci-drug-pipeline-v1Stage rulesApprovals feed →
Funnel
Drugs reach Malignant Rectal Neoplasm through trial conditions or approval indications mapped to it or to one of its descendant entities.
1 drug · 2 active trials
1 drug · 47 active trials
Data updated 4 hours agoSource updated unknownrecomputed with the intelligence layer
Drugs
Most advanced stage first, then most active trials. Trial counts are interventional studies linking the drug (and, when a cancer is selected, the cancer).
| Drug | Stage | Max phase | Active | Recruiting | Phase 3 | Total trials | Approvals | Jurisdictions | First approval | First trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Oxaliplatin | Phase 3 | Phase 3 | 39 | 21 | 17 | 112 | 0 | — | — | 1999-05 |
| Fluorouracil | Phase 3 | Phase 3 | 17 | 8 | 13 | 86 | 0 | — | — | 1997-05 |
| CAPOX Regimen | Phase 3 | Phase 3 | 14 | 5 | 8 | 23 | 0 | — | — | 2010-01 |
| Chemotherapy | Phase 3 | Phase 3 | 12 | 8 | 6 | 19 | 0 | — | — | Nov 3, 2009 |
| Bevacizumab | Phase 3 | Phase 3 | 9 | 5 | 9 | 52 | 0 | — | — | 2001-09 |
| FOLFOX Regimen | Phase 3 | Phase 3 | 9 | 3 | 2 | 15 | 0 | — | — | 2004-12 |
| Leucovorin | Phase 3 | Phase 3 | 7 | 4 | 9 | 53 | 0 | — | — | 1999-04 |
| Irinotecan | Phase 3 | Phase 3 | 7 | 2 | 5 | 41 | 0 | — | — | 1999-11 |
| Tislelizumab | Phase 3 | Phase 3 | 7 | 3 | 1 | 9 | 0 | — | — | Jun 22, 2020 |
| Cetuximab | Phase 3 | Phase 3 | 6 | 3 | 3 | 31 | 0 | — | — | 2003-12 |
| Serplulimab | Phase 3 | Phase 3 | 6 | 3 | 1 | 6 | 0 | — | — | Feb 22, 2023 |
| Immunotherapy | Phase 3 | Phase 3 | 3 | 0 | 1 | 4 | 0 | — | — | Nov 1, 2019 |
| Atezolizumab | Phase 3 | Phase 3 | 3 | 1 | 1 | 3 | 0 | — | — | Oct 22, 2019 |
| Celecoxib | Phase 3 | Phase 3 | 2 | 2 | 1 | 5 | 0 | — | — | 2000-03 |
| Chemoradiotherapy | Phase 3 | Phase 3 | 2 | 2 | 2 | 5 | 0 | — | — | 2005-09 |
| Pegfilgrastim | Phase 3 | Phase 3 | 0 | 0 | 1 | 2 | 0 | — | — | Feb 1, 2003 |
Stages describe registered activity and ingested regulatory records, not efficacy. Only ingested jurisdictions (currently US and Canada) can place a drug at "approved"; trial phases are as registered by sponsors. Nothing here is a treatment recommendation.