ALK Fusion

fusion

Identifier: CI-VAR-00001179
Entity page: /variant/v-alk-fusion ↗
Edges: 30

Neighbours: 10 cancers8 drugs
Drawn: 18 of 18 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
ALK Fusion predicts response to …PREDICTS_RESPONSE_TO15 of 19show all (up to 200)
→ predicts response to	Crizotinibsmall_molecule 5 source records aggregated	sensitivity	A	Anaplastic Large Cell Lymphoma,Inflammatory Myofibroblastic Tumor,Lung Non-Small Cell Carcinoma	5	Curated	civic

ALK Fusion diagnostic of …DIAGNOSTIC_OF1 of 1
→ diagnostic of	Inflammatory Myofibroblastic Tumorsubtype	supports	C	Inflammatory Myofibroblastic Tumor	1	Curated	civic	graph →

ALK Fusion has curated evidence in …HAS_EVIDENCE_INderived10 of 10
→ has curated evidence in	Lung Non-Small Cell Carcinoma 23 accepted items · levels A, B, C, D · 23 sensitivity / 0 resistance · 23 supports / 0 does not support	sensitivity	A	Lung Non-Small Cell Carcinoma	23	Curated	civic	graph →
→ has curated evidence in	Inflammatory Myofibroblastic Tumorsubtype 4 accepted items · levels A, B, C · 3 sensitivity / 0 resistance · 4 supports / 0 does not support	sensitivity	A	Inflammatory Myofibroblastic Tumor	4	Curated	civic	graph →
→ has curated evidence in	Anaplastic Large Cell Lymphoma 3 accepted items · levels A, B, C · 3 sensitivity / 0 resistance · 3 supports / 0 does not support	sensitivity	A	Anaplastic Large Cell Lymphoma	3	Curated	civic	graph →
→ has curated evidence in	Malignant Neoplasm 5 accepted items · levels B, D · 4 sensitivity / 1 resistance · 5 supports / 0 does not support	mixed	B	Malignant Neoplasm	5	Curated	civic	graph →
→ has curated evidence in	Lung Adenocarcinoma 2 accepted items · levels C · 1 sensitivity / 1 resistance · 2 supports / 0 does not support	mixed	C	Lung Adenocarcinoma	2	Curated	civic	graph →
→ has curated evidence in	Diffuse Large B-Cell Lymphoma 1 accepted items · levels C · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	C	Diffuse Large B-Cell Lymphoma	1	Curated	civic	graph →
→ has curated evidence in	Thyroid Gland Anaplastic Carcinoma 1 accepted items · levels C · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	C	Thyroid Gland Anaplastic Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Vaginal Sarcoma 1 accepted items · levels C · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	C	Vaginal Sarcoma	1	Curated	civic	graph →
→ has curated evidence in	Colorectal Adenocarcinoma 1 accepted items · levels E · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	E	Colorectal Adenocarcinoma	1	Curated	civic	graph →
→ has curated evidence in	Malignant Breast Neoplasm 1 accepted items · levels E · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	E	Malignant Breast Neoplasm	1	Curated	civic	graph →

Radial view

Every edge, grouped by relationship

Paths