ERBB2 Amplification

amplification

Identifier: CI-VAR-00000208
Entity page: /variant/erbb2-amplification ↗
Edges: 49

Neighbours: 15 cancers15 drugs
Drawn: 30 of 30 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
ERBB2 Amplification predicts response to …PREDICTS_RESPONSE_TO18 of 29show all (up to 200)
→ predicts response to	Trastuzumabmonoclonal_antibody 3 source records aggregated	sensitivity	A	Gastric Adenocarcinoma,HER2-Positive Breast Carcinoma	3	Curated	civic	graph →
predicts response to

ERBB2 Amplification prognostic in …PROGNOSTIC_IN1 of 1
→ prognostic in	Endometrial Serous Adenocarcinomasubtype	supports	B	Endometrial Serous Adenocarcinoma	1	Curated	civic	graph →

ERBB2 Amplification has curated evidence in …HAS_EVIDENCE_INderived15 of 19show all (up to 200)
→ has curated evidence in	HER2-Positive Breast Carcinoma 27 accepted items · levels A, B, D · 27 sensitivity / 0 resistance · 24 supports / 3 does not support	sensitivity	A	HER2-Positive Breast Carcinoma	27	Curated	civic	graph →
→ has curated evidence in	Malignant Breast Neoplasm 5 accepted items · levels A, D · 5 sensitivity / 0 resistance · 5 supports / 0 does not support	sensitivity	A	Malignant Breast Neoplasm	5	Curated	civic	graph →
→ has curated evidence in	Gastric Adenocarcinoma 3 accepted items · levels A, B · 3 sensitivity / 0 resistance · 3 supports / 0 does not support	sensitivity	A	Gastric Adenocarcinoma	3	Curated	civic	graph →
→ has curated evidence in	Malignant Colorectal Neoplasm 10 accepted items · levels B, D · 5 sensitivity / 5 resistance · 9 supports / 1 does not support	mixed	B	Malignant Colorectal Neoplasm	10	Curated	civic	graph →
→ has curated evidence in	Lung Non-Small Cell Carcinoma 4 accepted items · levels B, D · 4 sensitivity / 0 resistance · 1 supports / 3 does not support	sensitivity	B	Lung Non-Small Cell Carcinoma	4	Curated	civic	graph →
→ has curated evidence in	Endometrial Serous Adenocarcinomasubtype 2 accepted items · levels B, C · 1 sensitivity / 0 resistance · 2 supports / 0 does not support	sensitivity	B	Endometrial Serous Adenocarcinoma	2	Curated	civic	graph →
→ has curated evidence in	Bladder Carcinoma 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Bladder Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Childhood Ependymoma 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Childhood Ependymoma	1	Curated	civic	graph →
→ has curated evidence in	Malignant Biliary Tract Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Malignant Biliary Tract Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Malignant Endometrial Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 0 supports / 1 does not support	sensitivity	B	Malignant Endometrial Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Malignant Gastric Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Malignant Gastric Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Malignant Pancreatic Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Malignant Pancreatic Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Malignant Uterine Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 0 supports / 1 does not support	sensitivity	B	Malignant Uterine Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Salivary Gland Carcinoma 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Salivary Gland Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Cholangiocarcinoma 1 accepted items · levels C · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	C	Cholangiocarcinoma	1	Curated	civic	graph →

Radial view

Every edge, grouped by relationship

Paths