BRCA2 Mutation

other

Identifier: CI-VAR-00002650
Entity page: /variant/brca2-mutation ↗
Edges: 27

Neighbours: 13 cancers10 drugs
Drawn: 23 of 23 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
BRCA2 Mutation predicts response to …PREDICTS_RESPONSE_TO12 of 12
→ predicts response to	Rucaparibsmall_molecule 3 source records aggregated	sensitivity	A	Castration-Resistant Prostate Carcinoma,Malignant Ovarian Neoplasm	3	Curated	civic	graph →
→ predicts response to

BRCA2 Mutation prognostic in …PROGNOSTIC_IN2 of 2
→ prognostic in	Malignant Ovarian Neoplasmcancer	supports	B	Malignant Ovarian Neoplasm	1	Curated	civic	graph →
→ prognostic in	Ovarian Carcinomasubtype	supports	B	Ovarian Carcinoma	1	Curated	civic	graph →

BRCA2 Mutation has curated evidence in …HAS_EVIDENCE_INderived13 of 13
→ has curated evidence in	Malignant Ovarian Neoplasmcancer 8 accepted items · levels A, B · 7 sensitivity / 0 resistance · 8 supports / 0 does not support	sensitivity	A	Malignant Ovarian Neoplasm	8	Curated	civic	graph →
→ has curated evidence in	Ovarian Carcinomasubtype 4 accepted items · levels A, B · 3 sensitivity / 0 resistance · 4 supports / 0 does not support	sensitivity	A	Ovarian Carcinoma	4	Curated	civic	graph →
→ has curated evidence in	Castration-Resistant Prostate Carcinoma 2 accepted items · levels A · 2 sensitivity / 0 resistance · 2 supports / 0 does not support	sensitivity	A	Castration-Resistant Prostate Carcinoma	2	Curated	civic	graph →
→ has curated evidence in	Malignant Pancreatic Neoplasm 5 accepted items · levels B, C · 5 sensitivity / 0 resistance · 4 supports / 1 does not support	sensitivity	B	Malignant Pancreatic Neoplasm	5	Curated	civic	graph →
→ has curated evidence in	Triple-Negative Breast Carcinoma 2 accepted items · levels B · 2 sensitivity / 0 resistance · 1 supports / 1 does not support	sensitivity	B	Triple-Negative Breast Carcinoma	2	Curated	civic	graph →
→ has curated evidence in	Breast Carcinoma 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Breast Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Lung Carcinoma 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Lung Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Malignant Biliary Tract Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Malignant Biliary Tract Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Malignant Breast Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Malignant Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Malignant Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Malignant Prostate Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Malignant Prostate Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Malignant Uterine Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Malignant Uterine Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Solid Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Solid Neoplasm	1	Curated	civic	graph →

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