BRAF V600

Identifier: CI-VAR-00004571
Entity page: /variant/braf-v600 ↗
Edges: 32

Neighbours: 8 cancers10 drugs
Drawn: 18 of 18 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
BRAF V600 predicts response to …PREDICTS_RESPONSE_TO15 of 23show all (up to 200)
→ predicts response to	Cobimetinibsmall_molecule 2 source records aggregated	sensitivity	A	Melanoma	2	Curated	civic	graph →
→ predicts response to	Vemurafenibsmall_molecule 2 source records aggregated

BRAF V600 diagnostic of …DIAGNOSTIC_OF1 of 1
→ diagnostic of	Melanomacancer_family	supports	B	Melanoma	1	Curated	civic	graph →

BRAF V600 diagnostic of …DIAGNOSTIC_OF1 of 1

→ diagnostic of

Melanomacancer_family

supports

Melanoma

Curated

civic

graph →

BRAF V600 has curated evidence in …HAS_EVIDENCE_INderived8 of 8
→ has curated evidence in	Melanomacancer_family 13 accepted items · levels A, B, C, D · 9 sensitivity / 3 resistance · 13 supports / 0 does not support	mixed	A	Melanoma	13	Curated	civic	graph →
→ has curated evidence in	Childhood Low Grade Glioma 1 accepted items · levels A · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	A	Childhood Low Grade Glioma	1	Curated	civic	graph →
→ has curated evidence in	Cutaneous Melanoma 1 accepted items · levels A · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	A	Cutaneous Melanoma	1	Curated	civic	graph →
→ has curated evidence in	Malignant Colorectal Neoplasm 7 accepted items · levels B · 5 sensitivity / 2 resistance · 6 supports / 1 does not support	mixed	B	Malignant Colorectal Neoplasm	7	Curated	civic	graph →
→ has curated evidence in	Cholangiocarcinoma 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Cholangiocarcinoma	1	Curated	civic	graph →
→ has curated evidence in	Langerhans Cell Histiocytosis 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Langerhans Cell Histiocytosis	1	Curated	civic	graph →
→ has curated evidence in	Lung Non-Small Cell Carcinoma 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Histiocytic Sarcoma 1 accepted items · levels C · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	C	Histiocytic Sarcoma	1	Curated	civic	graph →

BRAF V600 has curated evidence in …HAS_EVIDENCE_INderived8 of 8

→ has curated evidence in

Melanomacancer_family

13 accepted items · levels A, B, C, D · 9 sensitivity / 3 resistance · 13 supports / 0 does not support

mixed

Melanoma

Curated

civic

graph →

→ has curated evidence in

Childhood Low Grade Glioma

1 accepted items · levels A · 1 sensitivity / 0 resistance · 1 supports / 0 does not support