I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

RECRUITING

Identifier: CI-TRIAL-00110516
Entity page: /trial/NCT01042379 ↗
Edges: 16

Neighbours: 5 cancers9 drugs
Drawn: 14 of 14 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer condition of …CONDITION_OFderived7 of 7
← condition of	Angiosarcoma registry condition “Angiosarcoma” mapped ONTOLOGY_EXACT	—	—	Angiosarcoma	1	Observed	clinicaltrials	graph →
← condition of	Breast Neoplasm registry condition “Breast Neoplasms” mapped ONTOLOGY_EXACT	—	—

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer intervention of …INTERVENTION_OFderived9 of 9
← intervention of	Cemiplimabmonoclonal antibody registry intervention “Cemiplimab” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Datopotamab Deruxtecanadc registry intervention “Datopotamab deruxtecan” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Ganetespibsmall molecule registry intervention “Ganetespib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Lasofoxifenesmall molecule registry intervention “Lasofoxifene” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Neratinibsmall molecule registry intervention “Neratinib” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Pertuzumab/Trastuzumab Regimen registry intervention “Pertuzumab and Trastuzumab” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Pexidartinibsmall molecule registry intervention “PLX3397” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Veliparibsmall molecule registry intervention “ABT-888” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →
← intervention of	Zanidatamabmonoclonal antibody registry intervention “Zanidatamab” (DRUG) mapped ALIAS	—	—	not mapped	1	Observed	clinicaltrials	graph →

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer intervention of …INTERVENTION_OFderived9 of 9

← intervention of

Cemiplimabmonoclonal antibody

registry intervention “Cemiplimab” (DRUG) mapped ALIAS

—

not mapped

Observed

clinicaltrials

graph →

← intervention of

Datopotamab Deruxtecanadc

registry intervention “Datopotamab deruxtecan” (DRUG) mapped ALIAS