WT1

WT1 transcription factor

Identifier: CI-GENE-00038916
Entity page: /gene/WT1 ↗
Edges: 1,589

Neighbours: 4 cancers15 variants
Drawn: 19 of 19 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
WT1 associated with …ASSOCIATED_WITH3 of 3
→ associated with	Acute Myeloid Leukemiahematologic_malignancy 8 source records aggregated	supports	B	Acute Myeloid Leukemia	8	Curated	civic	graph →
→ associated with	Desmoplastic Small Round Cell Tumorsubtype 2 source records aggregated

WT1 has variant …HAS_VARIANTderived15 of 1,583show all (up to 200)
→ has variant	Exon 7 Mutation 9 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	9	Curated	civic	graph →
→ has variant	Fusionfusion 3 accepted CIViC evidence items	—	—	Desmoplastic Small Round Cell Tumor	3	Curated	civic	graph →
→ has variant	Exon 9 Mutation 2 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	2	Curated	civic	graph →
→ has variant	Mutationsother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000011.10:g.(?_32389048)_(32435355_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000011.10:g.(?_32389058)_(32435345_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000011.10:g.(?_32396251)_(32417660_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000011.10:g.32396408deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000011.10:g.32438918G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000011.9:g.(?_32410594)_(32421600_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_024426.6(WT1):c.1000A>G (p.Thr334Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_024426.6(WT1):c.1002A>T (p.Thr334=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_024426.6(WT1):c.1004A>G (p.Glu335Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_024426.6(WT1):c.1008G>A (p.Gly336=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_024426.6(WT1):c.*100A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

WT1 has variant …HAS_VARIANTderived15 of 1,583show all (up to 200)

→ has variant

Exon 7 Mutation

9 accepted CIViC evidence items

—

Acute Myeloid Leukemia

Curated

WT1 altered in cohorts of …ALTERED_INderived3 of 3
→ altered in cohorts of	Acute Leukemia of Ambiguous Lineage 20 / 123 cases (16 %) · ssm · alal_target_gdc	—	—	Acute Leukemia of Ambiguous Lineage	1	Observed	cbioportal	graph →
→ altered in cohorts of	Acute Myeloid Leukemiahematologic_malignancy 72 / 903 cases (8.0 %) · ssm · aml_ohsu_2022 · largest of 4 cohorts	—	—	Acute Myeloid Leukemia	4	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 37 / 696 cases (5.3 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →

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