VHL

von Hippel-Lindau tumor suppressor

Identifier: CI-GENE-00038379
Entity page: /gene/VHL ↗
Edges: 2,766

Neighbours: 5 cancers15 variants
Drawn: 20 of 20 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
VHL associated with …ASSOCIATED_WITH8 of 8
→ associated with	Clear Cell Renal Cell Carcinomasubtype 3 source records aggregated	supports	B	Clear Cell Renal Cell Carcinoma	3	Curated	civic	graph →
→ associated with	Renal Cell Carcinomasubtype	supports

VHL has variant …HAS_VARIANTderived15 of 2,756show all (up to 200)
→ has variant	F76del (c.227_229del)deletion 19 accepted CIViC evidence items	—	—	not mapped	19	Curated	civic	graph →
→ has variant	R167W (c.499C>T)SNV 18 accepted CIViC evidence items	—	—	not mapped	18	Curated	civic	graph →
→ has variant	R167Q (c.500G>A)SNV 15 accepted CIViC evidence items	—	—	not mapped	15	Curated	civic	graph →
→ has variant	S65W (c.194C>G)SNV 15 accepted CIViC evidence items	—	—	not mapped	15	Curated	civic	graph →
→ has variant	S65L (c.194C>T)SNV 13 accepted CIViC evidence items	—	—	Clear Cell Renal Cell Carcinoma,Kidney Carcinoma	13	Curated	civic	graph →
→ has variant	R161* (c.481C>T)SNV 12 accepted CIViC evidence items	—	—	Renal Cell Carcinoma	12	Curated	civic	graph →
→ has variant	N78S (c.233A>G)SNV 11 accepted CIViC evidence items	—	—	not mapped	11	Curated	civic	graph →
→ has variant	R161Q (c.482G>A)SNV 10 accepted CIViC evidence items	—	—	not mapped	10	Curated	civic	graph →
→ has variant	Q195* (c.583C>T)SNV 9 accepted CIViC evidence items	—	—	not mapped	9	Curated	civic	graph →
→ has variant	Y98H (c.292T>C)SNV 9 accepted CIViC evidence items	—	—	not mapped	9	Curated	civic	graph →
→ has variant	F136S (c.407T>C)SNV 7 accepted CIViC evidence items	—	—	not mapped	7	Curated	civic	graph →
→ has variant	L118P (c.353T>C)SNV 7 accepted CIViC evidence items	—	—	Clear Cell Renal Cell Carcinoma	7	Curated	civic	graph →
→ has variant	L178P (c.533T>C)SNV 7 accepted CIViC evidence items	—	—	not mapped	7	Curated	civic	graph →
→ has variant	R113* (c.337C>T)SNV 7 accepted CIViC evidence items	—	—	not mapped	7	Curated	civic	graph →
→ has variant	C162W (c.486C>G)SNV 6 accepted CIViC evidence items	—	—	not mapped	6	Curated	civic	graph →

VHL altered in cohorts of …ALTERED_INderived2 of 2
→ altered in cohorts of	Clear Cell Renal Cell Carcinomasubtype 642 / 943 cases (68 %) · ssm · ccrcc_sjuh_2023 · largest of 10 cohorts	—	—	Clear Cell Renal Cell Carcinoma	10	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Cell Carcinomasubtype 237 / 352 cases (67 %) · ssm · rcc_cptac_gdc · largest of 2 cohorts	—	—	Renal Cell Carcinoma	2	Observed	cbioportal	graph →

Radial view

Every edge, grouped by relationship

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