TSC1

TSC complex subunit 1

Identifier: CI-GENE-00037230
Entity page: /gene/TSC1 ↗
Edges: 5,465

Neighbours: 7 cancers15 variants
Drawn: 22 of 22 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
TSC1 associated with …ASSOCIATED_WITH3 of 3
→ associated with	Bladder Carcinomasubtype	supports	B	Bladder Carcinoma	1	Curated	civic	graph →
→ associated with	Invasive Bladder Urothelial Carcinomasubtype	supports	C

TSC1 has variant …HAS_VARIANTderived15 of 5,458show all (up to 200)
→ has variant	Loss-of-function 2 accepted CIViC evidence items	—	—	Lung Adenocarcinoma,Bladder Carcinoma	2	Curated	civic	graph →
→ has variant	R1062WSNV 2 accepted CIViC evidence items	—	—	not mapped	2	Curated	civic	graph →
→ has variant	Frameshift Truncationindel 1 accepted CIViC evidence items	—	—	Invasive Bladder Urothelial Carcinoma	1	Curated	civic	graph →
→ has variant	mutationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000009.11:g.(135750586_135753559)_(135772997_135776102)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000009.11:g.(?_135771612)_(135778184_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000009.11:g.(?_135771612)_(135820530_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000009.11:g.(?_135771622)_(135804259_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000009.11:g.135773000_135773001insCAinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000009.11:g.(?_135776102)_(135787844_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000009.11:g.(?_135785948)_(135820530_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000009.11:g.(?_135798715)_(135804279_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000009.11:g.(?_135804148)_(135804265_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000009.11:g.(?_135819930)_(135820530_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000009.12:g.132691768_133013020deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

TSC1 has variant …HAS_VARIANTderived15 of 5,458show all (up to 200)

→ has variant

Loss-of-function

2 accepted CIViC evidence items

—

Lung Adenocarcinoma,Bladder Carcinoma

Curated

TSC1 altered in cohorts of …ALTERED_INderived4 of 4
→ altered in cohorts of	Endometrial Carcinoma 37 / 181 cases (20 %) · ssm · ucec_ccr_msk_2022	—	—	Endometrial Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 41 / 474 cases (8.6 %) · ssm · blca_msk_tcga_2020 · largest of 8 cohorts	—	—	Bladder Urothelial Carcinoma	8	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 40 / 696 cases (5.7 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 27 / 527 cases (5.1 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →

Radial view

Every edge, grouped by relationship

Paths