TOP1

DNA topoisomerase I

Identifier: CI-GENE-00035885
Entity page: /gene/TOP1 ↗
Edges: 17

Neighbours: 4 cancers5 variants8 drugs
Drawn: 17 of 17 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
TOP1 associated with …ASSOCIATED_WITH2 of 2
→ associated with	Malignant Colorectal Neoplasmsubtype 3 source records aggregated	supports	B	Malignant Colorectal Neoplasm	3	Curated	civic	graph →
→ associated with	Malignant Ovarian Neoplasmcancer	supports

TOP1 targets …TARGETS8 of 8
← targets	Trastuzumab Deruxtecanadc	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Trastuzumab Deruxtecanadc	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Topotecansmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sacituzumab Govitecanadc	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Patritumab Deruxtecanadc	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Irinotecansmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Datopotamab Deruxtecanadc	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	7-Ethyl-10-Hydroxycamptothecinsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

TOP1 targets …TARGETS8 of 8

← targets

Trastuzumab Deruxtecanadc

—

INHIBITOR

—

Curated

TOP1 has variant …HAS_VARIANTderived5 of 5
→ has variant	Amplificationamplification 2 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has variant	EXPRESSIONexpression 2 accepted CIViC evidence items	—	—	Malignant Ovarian Neoplasm,Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has variant	-122fsindel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E418KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Underexpressionexpression no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

TOP1 altered in cohorts of …ALTERED_INderived2 of 2
→ altered in cohorts of	Rectal Adenocarcinoma 152 / 171 cases (89 %) · ssm · TCGA-READ	—	—	Rectal Adenocarcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Colon Adenocarcinoma 325 / 461 cases (70 %) · ssm · TCGA-COAD	—	—	Colon Adenocarcinoma	1	Observed	gdc	graph →

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Every edge, grouped by relationship

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