RUNX1

RUNX family transcription factor 1

Identifier: CI-GENE-00029659
Entity page: /gene/RUNX1 ↗
Edges: 1,703

Neighbours: 6 cancers15 variants
Drawn: 21 of 21 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
RUNX1 associated with …ASSOCIATED_WITH5 of 5
→ associated with	B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1molecular_subtype	supports	A	B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1	1	Curated	civic	graph →
→ associated with	Acute Myeloid Leukemia

RUNX1 has variant …HAS_VARIANTderived15 of 1,694show all (up to 200)
→ has variant	Mutationother 6 accepted CIViC evidence items	—	—	Acute Lymphoblastic Leukemia,Acute Myeloid Leukemia	6	Curated	civic	graph →
→ has variant	Fusionfusion 4 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1	4	Curated	civic	graph →
→ has variant	A107PSNV 1 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	1	Curated	civic	graph →
→ has variant	D198YSNV 1 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	1	Curated	civic	graph →
→ has variant	K83ESNV 1 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	1	Curated	civic	graph →
→ has variant	R135FSX177 1 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	1	Curated	civic	graph →
→ has variant	T148HFSX9indel 1 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	1	Curated	civic	graph →
→ has variant	Y260*SNV 1 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	1	Curated	civic	graph →
→ has variant	A28fsX109 (c.83insG)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D96H (c.238G>C)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G336fs563X (c.1007_1013del)indel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K90fsX101 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000021.8:g.(?_36164422)_(36421595_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000021.8:g.(?_36164426)_(36231881_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000021.9:g.(?_34787801)_(34799462_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

RUNX1 altered in cohorts of …ALTERED_INderived4 of 4
→ altered in cohorts of	Acute Myeloid Leukemiahematologic_malignancy 108 / 903 cases (12 %) · ssm · aml_ohsu_2022 · largest of 2 cohorts	—	—	Acute Myeloid Leukemia	2	Observed	cbioportal	graph →
→ altered in cohorts of	Myelodysplastic Syndrome 408 / 4,231 cases (9.6 %) · ssm · mds_mskcc_2020 · largest of 2 cohorts	—	—	Myelodysplastic Syndrome	2	Observed	cbioportal	graph →
→ altered in cohorts of	Adenoid Cystic Carcinoma 71 / 1,049 cases (6.8 %) · ssm · acc_2019	—	—	Adenoid Cystic Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 33 / 527 cases (6.3 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →

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