PML

PML nuclear body scaffold

Identifier: CI-GENE-00020219
Entity page: /gene/PML ↗
Edges: 10

Neighbours: 1 cancers8 variants
Drawn: 9 of 9 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
PML associated with …ASSOCIATED_WITH2 of 2
→ associated with	Acute Promyelocytic Leukemiahematologic_malignancy 2 source records aggregated	supports	B	Acute Promyelocytic Leukemia	2	Curated	civic	graph →
→ associated with	Acute Promyelocytic Leukemiahematologic_malignancy 2 source records aggregated

PML has variant …HAS_VARIANTderived8 of 8
→ has variant	A216VSNV 2 accepted CIViC evidence items	—	—	Acute Promyelocytic Leukemia	2	Curated	civic	graph →
→ has variant	B2 DOMAIN MUTATIONSNV 1 accepted CIViC evidence items	—	—	Acute Promyelocytic Leukemia	1	Curated	civic	graph →
→ has variant	L218PSNV 1 accepted CIViC evidence items	—	—	Acute Promyelocytic Leukemia	1	Curated	civic	graph →
→ has variant	A216TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	K227_T233deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_033238.3(PML):c.2264G>C (p.Arg755Pro)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_033238.3(PML):c.919C>T (p.Arg307Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	S214LSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

PML has variant …HAS_VARIANTderived8 of 8

→ has variant

A216VSNV

2 accepted CIViC evidence items

—

Acute Promyelocytic Leukemia

Curated

civic

graph →

→ has variant

B2 DOMAIN MUTATIONSNV

1 accepted CIViC evidence items