MTHFR

methylenetetrahydrofolate reductase

Identifier: CI-GENE-00015559
Entity page: /gene/MTHFR ↗
Edges: 10

Neighbours: 3 cancers7 variants
Drawn: 10 of 10 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
MTHFR associated with …ASSOCIATED_WITH3 of 3
→ associated with	Malignant Gastric Neoplasmcancer	supports	B	Malignant Gastric Neoplasm	1	Curated	civic	graph →
→ associated with	Rectal Carcinomasubtype	supports	B

MTHFR has variant …HAS_VARIANTderived7 of 7
→ has variant	A222VSNV 3 accepted CIViC evidence items	—	—	Malignant Gastric Neoplasm,Prostate Adenocarcinoma,Rectal Carcinoma	3	Curated	civic	graph →
→ has variant	NM_005957.5(MTHFR):c.1286A>C (p.Glu429Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005957.5(MTHFR):c.154C>T (p.Arg52Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005957.5(MTHFR):c.1739del (p.Phe580fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005957.5(MTHFR):c.1753-48C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005957.5(MTHFR):c.236+1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005957.5(MTHFR):c.475+1G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

MTHFR has variant …HAS_VARIANTderived7 of 7

→ has variant

A222VSNV

3 accepted CIViC evidence items

—

Malignant Gastric Neoplasm,Prostate Adenocarcinoma,Rectal Carcinoma

Curated

civic

graph →

→ has variant

NM_005957.5(MTHFR):c.1286A>C (p.Glu429Ala)SNV

no accepted CIViC evidence item (variant record only)