MTHFR NM_005957.5(MTHFR):c.1286A>C (p.Glu429Ala)

CI-VAR-00005372Explore in graph →p.Glu429AlaNM_005957.5:c.1286A>CClinVar 3521 rs1801131

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
3521	Benign/Likely benign; other	criteria provided, multiple submitters, no conflicts	2	MTHFR THERMOLABILE POLYMORPHISM; Schizophrenia, susceptibility to; Gastrointestinal stromal tumor; Neural tube defects, folate-sensitive; Homocystinuria due to methylene tetrahydrofolate reductase deficiency; MTHFR-related disorder; Schizophrenia; Thrombophilia due to thrombin defect; Stroke disorder	germline	23	Feb 04, 2026	clinvar