MTAP

methylthioadenosine phosphorylase

Identifier: CI-GENE-00015282
Entity page: /gene/MTAP ↗
Edges: 128

Neighbours: 6 cancers15 variants
Drawn: 21 of 21 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
MTAP associated with …ASSOCIATED_WITH2 of 2
→ associated with	Solid Neoplasmcancer_family	supports	B	Solid Neoplasm	1	Curated	civic	graph →
→ associated with	Malignant Breast Neoplasmcancer_family	supports	D

MTAP has variant …HAS_VARIANTderived15 of 122show all (up to 200)
→ has variant	Deletiondeletion_cna 1 accepted CIViC evidence items	—	—	Solid Neoplasm	1	Curated	civic	graph →
→ has variant	Underexpressionexpression 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	NC_000009.12:g.21931006A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000009.12:g.21931079A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001396041.1(MTAP):c.1000A>G (p.Ser334Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002451.4(MTAP):c.*102A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002451.4(MTAP):c.*1038A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002451.4(MTAP):c.*1065A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002451.4(MTAP):c.*1093G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002451.4(MTAP):c.111A>G (p.Pro37=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002451.4(MTAP):c.*1140A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002451.4(MTAP):c.*1181A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002451.4(MTAP):c.*1197C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002451.4(MTAP):c.119A>G (p.Lys40Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002451.4(MTAP):c.121-10T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

MTAP has variant …HAS_VARIANTderived15 of 122show all (up to 200)

→ has variant

Deletiondeletion_cna

1 accepted CIViC evidence items

—

Solid Neoplasm

Curated

MTAP altered in cohorts of …ALTERED_INderived4 of 4
→ altered in cohorts of	Cutaneous Melanoma 351 / 470 cases (75 %) · ssm · TCGA-SKCM	—	—	Cutaneous Melanoma	1	Observed	gdc	graph →
→ altered in cohorts of	Esophageal Carcinoma 128 / 185 cases (69 %) · ssm · TCGA-ESCA	—	—	Esophageal Carcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 261 / 412 cases (63 %) · ssm · TCGA-BLCA	—	—	Bladder Urothelial Carcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Acute Lymphoblastic Leukemia 170 / 768 cases (22 %) · ssm · TARGET-ALL-P2	—	—	Acute Lymphoblastic Leukemia	1	Observed	gdc	graph →

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Every edge, grouped by relationship

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