MERTK

MER proto-oncogene, tyrosine kinase

Identifier: CI-GENE-00012401
Entity page: /gene/MERTK ↗
Edges: 10

Neighbours: 1 cancers8 variants1 drugs
Drawn: 10 of 10 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
MERTK associated with …ASSOCIATED_WITH1 of 1
→ associated with	Melanomacancer_family	supports	D	Melanoma	1	Curated	civic	graph →
MERTK targets …TARGETS1 of 1
← targets	Ningetinib

MERTK has variant …HAS_VARIANTderived8 of 8
→ has variant	OVEREXPRESSIONexpression 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	NM_006343.3(MERTK):c.1296+1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006343.3(MERTK):c.2080-11C>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006343.3(MERTK):c.2189+1G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006343.3(MERTK):c.60A>T (p.Arg20Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006343.3(MERTK):c.756A>C (p.Pro252=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006343.3(MERTK):c.756A>G (p.Pro252=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_006343.3(MERTK):c.844G>A (p.Ala282Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

MERTK has variant …HAS_VARIANTderived8 of 8

→ has variant

OVEREXPRESSIONexpression

1 accepted CIViC evidence items

—

Melanoma

Curated

civic

graph →

→ has variant

NM_006343.3(MERTK):c.1296+1G>ASNV

no accepted CIViC evidence item (variant record only)