MAP2K2

mitogen-activated protein kinase kinase 2

Identifier: CI-GENE-00011952
Entity page: /gene/MAP2K2 ↗
Edges: 23

Neighbours: 1 cancers15 variants7 drugs
Drawn: 23 of 23 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
MAP2K2 associated with …ASSOCIATED_WITH1 of 1
→ associated with	Melanomacancer_family 3 source records aggregated	supports	D	Melanoma	3	Curated	civic	graph →
MAP2K2 targets …TARGETS7 of 7
← targets

MAP2K2 has variant …HAS_VARIANTderived15 of 15
→ has variant	C125SSNV 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	L46FSNV 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	N126DSNV 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	F57CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G132DSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G132SSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	H123QSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Mutationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_030662.4(MAP2K2):c.1092+127G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_030662.4(MAP2K2):c.274A>G (p.Arg92Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_030662.4(MAP2K2):c.303+18G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_030662.4(MAP2K2):c.304-12C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_030662.4(MAP2K2):c.415A>G (p.Ser139Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_030662.4(MAP2K2):c.450+17C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	V35MSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

Radial view

Every edge, grouped by relationship

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