HSP90AA1

heat shock protein 90 alpha family class A member 1

Identifier: CI-GENE-00005105
Entity page: /gene/HSP90AA1 ↗
Edges: 8

Neighbours: 2 variants6 drugs
Drawn: 8 of 8 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
HSP90AA1 targets …TARGETS6 of 6
← targets	Tanespimycinsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Retaspimycin Hydrochloridesmall_molecule	—	INHIBITOR	—	1	Curated	chembl

HSP90AA1 has variant …HAS_VARIANTderived2 of 2
→ has variant	NM_005348.4(HSP90AA1):c.1338+9A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005348.4(HSP90AA1):c.739_741del (p.Lys247del)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

HSP90AA1 has variant …HAS_VARIANTderived2 of 2

→ has variant

NM_005348.4(HSP90AA1):c.1338+9A>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005348.4(HSP90AA1):c.739_741del (p.Lys247del)deletion

no accepted CIViC evidence item (variant record only)