HIF1A

hypoxia inducible factor 1 subunit alpha

Identifier: CI-GENE-00004385
Entity page: /gene/HIF1A ↗
Edges: 10

Neighbours: 3 cancers7 variants
Drawn: 10 of 10 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
HIF1A associated with …ASSOCIATED_WITH3 of 3
→ associated with	Sarcomacancer_family	supports	B	Sarcoma	1	Curated	civic	graph →
→ associated with	Pancreatic Adenocarcinomasubtype	supports	B

HIF1A has variant …HAS_VARIANTderived7 of 7
→ has variant	OVEREXPRESSIONexpression 2 accepted CIViC evidence items	—	—	Sarcoma,Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has variant	3' UTR PolymorphismSNV 1 accepted CIViC evidence items	—	—	Pancreatic Adenocarcinoma	1	Curated	civic	graph →
→ has variant	EXPRESSIONexpression 1 accepted CIViC evidence items	—	—	Renal Cell Carcinoma	1	Curated	civic	graph →
→ has variant	NM_001530.4(HIF1A):c.1065A>T (p.Gln355His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001530.4(HIF1A):c.1744C>T (p.Pro582Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001530.4(HIF1A):c.700G>A (p.Glu234Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001530.4(HIF1A):c.774-3C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

HIF1A has variant …HAS_VARIANTderived7 of 7

→ has variant

OVEREXPRESSIONexpression

2 accepted CIViC evidence items

—

Sarcoma,Malignant Colorectal Neoplasm

Curated

civic

graph →

→ has variant

3' UTR PolymorphismSNV

1 accepted CIViC evidence items