HDAC8

histone deacetylase 8

Identifier: CI-GENE-00004250
Entity page: /gene/HDAC8 ↗
Edges: 13

Neighbours: 7 variants6 drugs
Drawn: 13 of 13 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
HDAC8 targets …TARGETS6 of 6
← targets	Romidepsinother	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Quisinostatsmall_molecule	—	INHIBITOR	—	1	Curated	chembl

HDAC8 has variant …HAS_VARIANTderived7 of 7
→ has variant	NM_018486.3(HDAC8):c.1005+2T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_018486.3(HDAC8):c.1006-2A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_018486.3(HDAC8):c.1112-2A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_018486.3(HDAC8):c.112-1G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_018486.3(HDAC8):c.418G>A (p.Gly140Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_018486.3(HDAC8):c.423G>A (p.Trp141Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_018486.3(HDAC8):c.910G>A (p.Gly304Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →

HDAC8 has variant …HAS_VARIANTderived7 of 7

→ has variant

NM_018486.3(HDAC8):c.1005+2T>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_018486.3(HDAC8):c.1006-2A>GSNV

no accepted CIViC evidence item (variant record only)