HDAC4

histone deacetylase 4

Identifier: CI-GENE-00004243
Entity page: /gene/HDAC4 ↗
Edges: 11

Neighbours: 6 variants5 drugs
Drawn: 11 of 11 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
HDAC4 targets …TARGETS5 of 5
← targets	Romidepsinother	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Quisinostatsmall_molecule	—	INHIBITOR	—	1	Curated	chembl

HDAC4 has variant …HAS_VARIANTderived6 of 6
→ has variant	NM_001378414.1(HDAC4):c.1580C>T (p.Pro527Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001378414.1(HDAC4):c.2371G>A (p.Ala791Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001378414.1(HDAC4):c.2444+175A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001378414.1(HDAC4):c.2823G>C (p.Val941=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001378414.1(HDAC4):c.317C>T (p.Ala106Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001378414.1(HDAC4):c.3231-99G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →

HDAC4 has variant …HAS_VARIANTderived6 of 6

→ has variant

NM_001378414.1(HDAC4):c.1580C>T (p.Pro527Leu)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_001378414.1(HDAC4):c.2371G>A (p.Ala791Thr)SNV

no accepted CIViC evidence item (variant record only)