ESR2

estrogen receptor 2

Identifier: CI-GENE-00001028
Entity page: /gene/ESR2 ↗
Edges: 11

Neighbours: 7 variants4 drugs
Drawn: 11 of 11 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
ESR2 targets …TARGETS4 of 4
← targets	Toremifenesmall_molecule	—	MODULATOR	—	1	Curated	chembl	graph →
← targets	Lasofoxifenesmall_molecule	—	MODULATOR	—	1	Curated	chembl

ESR2 has variant …HAS_VARIANTderived7 of 7
→ has variant	alternative transcripts no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	beta-2 and beta-5 no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001437.3(ESR2):c.1092-232T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001437.3(ESR2):c.1226-2A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001437.3(ESR2):c.633A>G (p.Glu211=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001437.3(ESR2):c.7A>G (p.Ile3Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	underexpression beta-1expression no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →

ESR2 has variant …HAS_VARIANTderived7 of 7

→ has variant

alternative transcripts

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

beta-2 and beta-5

no accepted CIViC evidence item (variant record only)