CYP11A1

cytochrome P450 family 11 subfamily A member 1

Identifier: CI-GENE-00042829
Entity page: /gene/CYP11A1 ↗
Edges: 4

Neighbours: 2 variants2 drugs
Drawn: 4 of 4 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
CYP11A1 targets …TARGETS2 of 2
← targets	Mitotanesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Aminoglutethimidesmall_molecule	—	INHIBITOR	—	1	Curated	chembl

CYP11A1 has variant …HAS_VARIANTderived2 of 2
→ has variant	NM_000781.3(CYP11A1):c.269+1460C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000781.3(CYP11A1):c.566C>T (p.Ala189Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

CYP11A1 has variant …HAS_VARIANTderived2 of 2

→ has variant

NM_000781.3(CYP11A1):c.269+1460C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000781.3(CYP11A1):c.566C>T (p.Ala189Val)SNV

no accepted CIViC evidence item (variant record only)