BRCA1

BRCA1 DNA repair associated

Identifier: CI-GENE-00022042
Entity page: /gene/BRCA1 ↗
Edges: 13,220

Neighbours: 17 cancers15 variants
Drawn: 32 of 32 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
BRCA1 associated with …ASSOCIATED_WITH15 of 24show all (up to 200)
→ associated with	Malignant Ovarian Neoplasmcancer 4 source records aggregated	supports	A	Malignant Ovarian Neoplasm	4	Curated	civic	graph →
→ associated with	Castration-Resistant Prostate Carcinoma

BRCA1 has variant …HAS_VARIANTderived15 of 13,191show all (up to 200)
→ has variant	Mutationother 29 accepted CIViC evidence items	—	—	Malignant Neoplasm,Solid Neoplasm,Breast Carcinoma+2	29	Curated	civic	graph →
→ has variant	Loss-of-functionloss_of_heterozygosity 11 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Mesothelioma,Malignant Ovarian Neoplasm+2	11	Curated	civic	graph →
→ has variant	P968FSindel 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Ovarian Neoplasm	2	Curated	civic	graph →
→ has variant	Alu insertioninsertion 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	Expressionexpression 1 accepted CIViC evidence items	—	—	Malignant Mesothelioma	1	Curated	civic	graph →
→ has variant	Q1467*SNV 1 accepted CIViC evidence items	—	—	Malignant Ovarian Neoplasm	1	Curated	civic	graph →
→ has variant	Underexpressionexpression 1 accepted CIViC evidence items	—	—	Malignant Ovarian Neoplasm	1	Curated	civic	graph →
→ has variant	W1815XSNV 1 accepted CIViC evidence items	—	—	Ovarian Endometrioid Adenocarcinoma	1	Curated	civic	graph →
→ has variant	4586INS5insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A1708ESNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A1789TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	ATM no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	b no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	c.212+1G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C61GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

BRCA1 altered in cohorts of …ALTERED_INderived5 of 5
→ altered in cohorts of	Skin Basal Cell Carcinoma 49 / 293 cases (17 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	High-Grade Serous Ovarian Cancer 37 / 316 cases (12 %) · ssm · ov_tcga_pub	—	—	High-Grade Serous Ovarian Cancer	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 43 / 527 cases (8.2 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 43 / 696 cases (6.2 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 26 / 474 cases (5.5 %) · ssm · blca_msk_tcga_2020 · largest of 2 cohorts	—	—	Bladder Urothelial Carcinoma	2	Observed	cbioportal	graph →

Radial view

Every edge, grouped by relationship

Paths