ASXL1

ASXL transcriptional regulator 1

Identifier: CI-GENE-00011589
Entity page: /gene/ASXL1 ↗
Edges: 32

Neighbours: 11 cancers20 variants
Drawn: 31 of 31 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
ASXL1 associated with …ASSOCIATED_WITH2 of 2
→ associated with	Acute Myeloid Leukemiahematologic_malignancy 6 source records aggregated	supports	B	Acute Myeloid Leukemia	6	Curated	civic	graph →
→ associated with	Primary Myelofibrosishematologic_malignancy	supports

ASXL1 has variant …HAS_VARIANTderived20 of 20show fewer
→ has variant	Mutationother 6 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia,Primary Myelofibrosis	6	Curated	civic	graph →
→ has variant	EXON 12 MUTATION 1 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	1	Curated	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.140+26A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.1544_1545del (p.Val515fs)other no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.1654A>G (p.Ile552Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.1720-2A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.1820del (p.Gly607fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.1892_1938del (p.His631fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.1900_1922del (p.Glu635fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.1910C>G (p.Ala637Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.1934del (p.Gly645fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.1934dup (p.Gly646fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.1975G>A (p.Gly659Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.2001T>G (p.Asp667Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.2572C>T (p.Gln858Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.2926C>T (p.Gln976Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.2929C>T (p.Gln977Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.3008_3009del (p.Ala1002_Ser1003insTer)other no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.4240C>A (p.Pro1414Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_015338.6(ASXL1):c.566-198A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

ASXL1 has variant …HAS_VARIANTderived20 of 20show fewer

→ has variant

Mutationother

6 accepted CIViC evidence items

—

Acute Myeloid Leukemia,Primary Myelofibrosis

Curated

ASXL1 altered in cohorts of …ALTERED_INderived10 of 10
→ altered in cohorts of	Colon Adenocarcinoma 334 / 461 cases (72 %) · ssm · TCGA-COAD	—	—	Colon Adenocarcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Skin Basal Cell Carcinoma 46 / 293 cases (16 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Myeloid Neoplasm 21 / 136 cases (15 %) · ssm · mnm_washu_2016	—	—	Myeloid Neoplasm	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 21 / 181 cases (12 %) · ssm · ucec_ccr_msk_2022	—	—	Endometrial Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Acute Myeloid Leukemiahematologic_malignancy 93 / 903 cases (10 %) · ssm · aml_ohsu_2022 · largest of 2 cohorts	—	—	Acute Myeloid Leukemia	2	Observed	cbioportal	graph →
→ altered in cohorts of	Myelodysplastic Syndrome 434 / 4,231 cases (10 %) · ssm · mds_mskcc_2020 · largest of 2 cohorts	—	—	Myelodysplastic Syndrome	2	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 54 / 696 cases (7.8 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 33 / 527 cases (6.3 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 27 / 474 cases (5.7 %) · ssm · blca_msk_tcga_2020 · largest of 2 cohorts	—	—	Bladder Urothelial Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 410 / 7,237 cases (5.7 %) · ssm · crc_msk_2026 · largest of 2 cohorts	—	—	Rectal Adenocarcinoma	2	Observed	cbioportal	graph →

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