AKT3

AKT serine/threonine kinase 3

Identifier: CI-GENE-00000868
Entity page: /gene/AKT3 ↗
Edges: 18

Neighbours: 3 cancers11 variants4 drugs
Drawn: 18 of 18 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
AKT3 associated with …ASSOCIATED_WITH3 of 3
→ associated with	Melanomacancer_family 2 source records aggregated	supports	D	Melanoma	2	Curated	civic	graph →
→ associated with	Malignant Breast Neoplasmcancer_family	supports	D

AKT3 targets …TARGETS4 of 4
← targets	Uprosertibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Ipatasertibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Capivasertibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	ARQ092small_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

AKT3 targets …TARGETS4 of 4

← targets

Uprosertibsmall_molecule

—

INHIBITOR

—

Curated

AKT3 has variant …HAS_VARIANTderived11 of 11
→ has variant	Overexpressionexpression 3 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Melanoma,Triple-Negative Breast Carcinoma	3	Curated	civic	graph →
→ has variant	E17KSNV 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	D320HSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	DEPLETION no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	L51RSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005465.7(AKT3):c.1393C>T (p.Arg465Trp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005465.7(AKT3):c.*5452G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005465.7(AKT3):c.*5453T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005465.7(AKT3):c.819+189G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005465.7(AKT3):c.819+2T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	UPREGULATION no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

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