Safusidenib

small molecule

Identifier: CI-DRUG-00000538
Entity page: /drug/safusidenib ↗
Edges: 17

Neighbours: 10 cancers1 genes6 trials
Drawn: 17 of 17 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Safusidenib targets …TARGETS1 of 1
→ targets	IDH1	—	INHIBITOR	—	1	Curated	chembl	graph →
Safusidenib investigated for …INVESTIGATED_FOR2 of 2
→ investigated for	Neoplasmcancer_family	unknown	2

Safusidenib investigated in trials for …INVESTIGATED_IN_TRIALSderived8 of 8
→ investigated in trials for	Astrocytoma, IDH-Mutant, Grade 2 3 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Astrocytoma, IDH-Mutant, Grade 2	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Glioma 3 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Glioma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Oligodendroglioma 3 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Oligodendroglioma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Astrocytoma, IDH-Mutant, Grade 3 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Astrocytoma, IDH-Mutant, Grade 3	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Astrocytoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Astrocytoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Astrocytoma, IDH-Mutant, Grade 4 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Astrocytoma, IDH-Mutant, Grade 4	1	Observed	clinicaltrials	graph →
→ investigated in trials for	WHO Grade 2 Glioma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	WHO Grade 2 Glioma	1	Observed	clinicaltrials	graph →

Safusidenib studied in …STUDIED_INderived6 of 6
→ studied in	NCT07703436Phase 2 · not yet recruiting Safety and Efficacy Study of Safusidenib in Participants With IDH1-Mutant Glioma Who Discontinued Vorasidenib Treatment Due to Progressive Disease · 6 trials list this drug (5 active)	—	—	Glioma,Astrocytoma, IDH-Mutant, Grade 3,Oligodendroglioma+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT07832123Phase 2 · not yet recruiting Safusidenib for Patients With Newly Diagnosed IDH1-mutant CNS WHO Grade 3 Oligodendroglioma and Astrocytoma - a Single Arm Phase II Study · 6 trials list this drug (5 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT05303519Phase 3 · recruiting SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance) · 6 trials list this drug (5 active)	—	—	Astrocytoma, IDH-Mutant, Grade 4,Glioma,Astrocytoma, IDH-Mutant, Grade 3+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT03030066Phase 1 · completed Study of DS-1001b in Patients With Gene IDH1-Mutated Gliomas · 6 trials list this drug (5 active)	—	—	Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07712757Phase 3 · not yet recruiting Safety and Efficacy Study of Safusidenib in Participants With Grade 2 IDH1-Mutant Glioma · 6 trials list this drug (5 active)	—	—	Oligodendroglioma,Astrocytoma, IDH-Mutant, Grade 2,Oligodendroglioma, IDH-Mutant and 1p/19q-Codeleted	1	Observed	clinicaltrials	graph →
→ studied in	NCT04458272Phase 2 · active not recruiting A Study of DS-1001b in Patients With Chemotherapy- and Radiotherapy-Naive IDH1 Mutated WHO Grade II Glioma · 6 trials list this drug (5 active)	—	—	WHO Grade 2 Glioma	1	Observed	clinicaltrials	graph →

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