Omacetaxine Mepesuccinate

small molecule

Identifier: CI-DRUG-00000418
Entity page: /drug/omacetaxine-mepesuccinate ↗
Edges: 71

Neighbours: 17 cancers10 trials
Drawn: 27 of 27 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Omacetaxine Mepesuccinate investigated for …INVESTIGATED_FOR5 of 5
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Leukemiacancer_family	unknown	3

Omacetaxine Mepesuccinate investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 32show all (up to 200)
→ investigated in trials for	Acute Myeloid Leukemiahematologic_malignancy 12 trials (7 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Myeloid Leukemia	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Chronic Myeloid Leukemia, BCR-ABL1 Positivemolecular_subtype 6 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Chronic Myeloid Leukemia, BCR-ABL1 Positive	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Leukemiacancer_family 4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Leukemia	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Acute Myeloid Leukemia 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Acute Myeloid Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Hematopoietic and Lymphoid Cell Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hematopoietic and Lymphoid Cell Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Biphenotypic Leukemia 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Biphenotypic Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Lymphoblastic Leukemia 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Myeloid Leukemia with del(5q) 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Myeloid Leukemia with del(5q)	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Acute Megakaryoblastic Leukemia 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Acute Megakaryoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Acute Monoblastic Leukemia 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Acute Monoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Acute Monocytic Leukemia 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Acute Monocytic Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Acute Myeloid Leukemia with Maturation 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Acute Myeloid Leukemia with Maturation	1	Observed	clinicaltrials	graph →

Omacetaxine Mepesuccinate investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 32show all (up to 200)

→ investigated in trials for

Acute Myeloid Leukemiahematologic_malignancy

12 trials (7 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Acute Myeloid Leukemia

Observed

Omacetaxine Mepesuccinate studied in …STUDIED_INderived10 of 34show all (up to 200)
→ studied in	NCT07813390Phase 2 · enrolling by invitation Homoharringtonine, Lisaftoclax, and Azacitidine for AML After Venetoclax-Based Therapy Failure · 34 trials list this drug (15 active)	—	—	Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07131059NA · recruiting MRD-positive AML Clinical Study · 34 trials list this drug (15 active)	—	—	Adult Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT06265545NA · recruiting Multicenter, Platform-type Clinical Study of Refractory/Recurrent Acute Myeloid Leukemia · 34 trials list this drug (15 active)	—	—	Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT06744556Phase 2 · active not recruiting HAV Versus DAV/IAV Induction Regimen in Elderly Patients With AML · 34 trials list this drug (15 active)	—	—	Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT04501120Phase 1/Phase 2 · recruiting Study of Lisaftoclax (APG-2575) Single Agent and Combination With Therapy in Patients Relapsed/Refractory AML · 34 trials list this drug (15 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT07469046Phase 3 · not yet recruiting VAH vs VA in Newly Diagnosed Elderly AML · 34 trials list this drug (15 active)	—	—	Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07505160Phase 2 · not yet recruiting Efficacy and Safety of Lisafotoclax Plus Decitabine and Homoharringtonine in Venetoclax/Azacitidine Pretreated AML Patients · 34 trials list this drug (15 active)	—	—	Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07163910Phase 2 · recruiting Homoharringtonine Plus Androgen Deprivation Therapy in the Neoadjuvant Treatment of Prostate Cancer: A Single-Arm Clinical Study · 34 trials list this drug (15 active)	—	—	Malignant Prostate Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04874194Phase 1/Phase 2 · terminated Omacetaxine and Venetoclax for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome Harboring Mutant RUNX1 · 34 trials list this drug (15 active)	—	—	Hematopoietic and Lymphoid Cell Neoplasm,Myelodysplastic Syndrome,Acute Myeloid Leukemia+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT07159906Phase 1/Phase 2 · not yet recruiting Homoharringtonine, BCL-2 Inhibitor, Rituximab, and Prednisone in Relapsed/Refractory Diffuse Large B-Cell Lymphoma · 34 trials list this drug (15 active)	—	—	Non-Hodgkin Lymphoma,Diffuse Large B-Cell Lymphoma	1	Observed	clinicaltrials	graph →

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