Mechlorethamine

small molecule

Identifier: CI-DRUG-00000675
Entity page: /drug/mechlorethamine ↗
Edges: 28

Neighbours: 9 cancers10 trials1 approvals
Drawn: 20 of 20 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Mechlorethamine approved for …APPROVED_FOR2 of 1
→ approved for	Mycosis Fungoideshematologic_malignancy	supports	FDA ORIG	Mycosis Fungoides	1	Regulatory	openfda	graph →
→ approved for	Health Canada · CA · 1951Marketed in Canada as MUSTARGEN (DIN 00016063) under ATC L01AA05 CHLORMETHINE. Indications are not published in the Drug Product Database — see the Health Canada Product Monograph.

Mechlorethamine investigated for …INVESTIGATED_FOR6 of 6
→ investigated for	Primary Cutaneous T-Cell Non-Hodgkin Lymphomahematologic_malignancy	unknown	4	Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Mycosis Fungoideshematologic_malignancy	unknown	4	Mycosis Fungoides	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	3	Lymphoma	1	Curated	chembl	graph →
→ investigated for	Central Nervous System Neoplasmcancer_family	unknown	2	Central Nervous System Neoplasm	1	Curated	chembl	graph →
→ investigated for	Hodgkin Lymphomahematologic_malignancy	unknown	2	Hodgkin Lymphoma	1	Curated	chembl	graph →

Mechlorethamine investigated for …INVESTIGATED_FOR6 of 6

→ investigated for

Primary Cutaneous T-Cell Non-Hodgkin Lymphomahematologic_malignancy

unknown

Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

Curated

Mechlorethamine investigated in trials for …INVESTIGATED_IN_TRIALSderived6 of 6
→ investigated in trials for	Lymphomacancer_family 8 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoma	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Mycosis Fungoideshematologic_malignancy 6 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Mycosis Fungoides	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Primary Cutaneous T-Cell Non-Hodgkin Lymphomahematologic_malignancy 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Folliculotropic Mycosis Fungoides 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Folliculotropic Mycosis Fungoides	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Mycosis Fungoides Variant 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Mycosis Fungoides Variant	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Transformed Mycosis Fungoides 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Transformed Mycosis Fungoides	1	Observed	clinicaltrials	graph →

Mechlorethamine studied in …STUDIED_INderived10 of 15show all (up to 200)
→ studied in	NCT03380026Phase 2 · completed Mechlorethamine Induced Contact Dermatitis Avoidance Study · 15 trials list this drug (2 active)	—	—	Primary Cutaneous T-Cell Non-Hodgkin Lymphoma,Mycosis Fungoides,Mycosis Fungoides Variant+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT06149247Phase 2 · completed HyBryte (Synthetic Hypericin) Versus Valchlor (Mechlorethamine) in the Treatment of CTCL · 15 trials list this drug (2 active)	—	—	Mycosis Fungoides	1	Observed	clinicaltrials	graph →
→ studied in	NCT00002462Phase 3 · active not recruiting RT or No RT Following Chemotherapy in Treating Patients With Stage III/IV Hodgkin's Disease · 15 trials list this drug (2 active)	—	—	Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00379041Phase 3 · active not recruiting Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Previously Untreated Stage I or Stage II Hodgkin's Lymphoma · 15 trials list this drug (2 active)	—	—	Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03288818Phase 2 · withdrawn Low Dose Total Skin Electron Beam Radiation Therapy and Mechlorethamine Hydrochloride Gel in Treating Patients With Mycosis Fungoides · 15 trials list this drug (2 active)	—	—	Mycosis Fungoides	1	Observed	clinicaltrials	graph →
→ studied in	NCT00574496Phase 2 · completed Combination Chemotherapy Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or High-Risk Primary Refractory Hodgkin Lymphoma · 15 trials list this drug (2 active)	—	—	Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00003389Phase 3 · completed Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma · 15 trials list this drug (2 active)	—	—	Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00002715Phase 2 · completed Combination Chemotherapy in Treating Patients With Advanced Hodgkin's Lymphoma · 15 trials list this drug (2 active)	—	—	Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02296164completed Clinical Study Assessing Outcomes, Adverse Events, Treatment Patterns, and Quality of Life in Patients Diagnosed With Mycosis Fungoides Cutaneous T-cell Lymphoma · 15 trials list this drug (2 active)	—	—	Mycosis Fungoides	1	Observed	clinicaltrials	graph →
→ studied in	NCT02881749Phase 2 · unknown Low Dose Total Skin Electron Beam Treatment (TSEBT) Followed by Maintenance Valchlor for Patients With Mycosis Fungoides · 15 trials list this drug (2 active)	—	—	Primary Cutaneous T-Cell Non-Hodgkin Lymphoma,Mycosis Fungoides	1	Observed	clinicaltrials	graph →

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