Undifferentiated Pleomorphic Sarcoma

subtype

Identifier: CI-CAN-00006994
Entity page: /cancer/undifferentiated-pleomorphic-sarcoma ↗
Edges: 86

Neighbours: 17 drugs10 trials
Drawn: 27 of 27 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Undifferentiated Pleomorphic Sarcoma investigated for …INVESTIGATED_FOR6 of 6
← investigated for	Toripalimabmonoclonal_antibody	unknown	2	Undifferentiated Pleomorphic Sarcoma	1	Curated	chembl	graph →
← investigated for	Sintilimabmonoclonal_antibody	unknown	2

Undifferentiated Pleomorphic Sarcoma investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 27show all (up to 200)
→ investigated in trials for	Doxorubicinsmall molecule 9 trials (6 active) · roll-up of the cancer and its descendants	—	—	Undifferentiated Pleomorphic Sarcoma	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Pembrolizumabmonoclonal_antibody 6 trials (4 active) · roll-up of the cancer and its descendants	—	—	Undifferentiated Pleomorphic Sarcoma	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Ipilimumabmonoclonal_antibody 5 trials (2 active) · roll-up of the cancer and its descendants	—	—	Undifferentiated Pleomorphic Sarcoma	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Gemcitabinesmall molecule 4 trials (0 active) · roll-up of the cancer and its descendants	—	—	Undifferentiated Pleomorphic Sarcoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Ifosfamidesmall molecule 4 trials (3 active) · roll-up of the cancer and its descendants	—	—	Undifferentiated Pleomorphic Sarcoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal_antibody 4 trials (3 active) · roll-up of the cancer and its descendants	—	—	Undifferentiated Pleomorphic Sarcoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Docetaxelsmall molecule 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Undifferentiated Pleomorphic Sarcoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Pazopanibsmall molecule 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Undifferentiated Pleomorphic Sarcoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Toripalimabmonoclonal_antibody 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Undifferentiated Pleomorphic Sarcoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Alisertibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Undifferentiated Pleomorphic Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Avelumabmonoclonal antibody 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Undifferentiated Pleomorphic Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Cabozantinibsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	Undifferentiated Pleomorphic Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Eribulinsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Undifferentiated Pleomorphic Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Erlotinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Undifferentiated Pleomorphic Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Futibatinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Undifferentiated Pleomorphic Sarcoma	1	Observed	clinicaltrials	graph →

Undifferentiated Pleomorphic Sarcoma investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 27show all (up to 200)

→ investigated in trials for

Doxorubicinsmall molecule

9 trials (6 active) · roll-up of the cancer and its descendants

—

Undifferentiated Pleomorphic Sarcoma studied in …STUDIED_INderived10 of 53show all (up to 200)
→ studied in	NCT02923778Phase 2 · active not recruiting Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery · condition mapped ONTOLOGY_EXACT · 53 trials mapped (21 active)	—	—	Undifferentiated Pleomorphic Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06422806Phase 3 · recruiting Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas · condition mapped CURATED_BROADER · 53 trials mapped (21 active)	—	—	Undifferentiated Pleomorphic Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07823491Phase 3 · not yet recruiting Pembrolizumab and Radiation Therapy With or Without Neoadjuvant Doxorubicin and Ifosfamide for the Treatment of High-Risk Resectable Undifferentiated Pleomorphic Sarcoma or Liposarcoma of the Extremity or Trunk Wall · condition mapped CURATED_BROADER · 53 trials mapped (21 active)	—	—	Undifferentiated Pleomorphic Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07802652Phase 2 · not yet recruiting Doxorubicin With or Without DT-7012 in Advanced Soft Tissue Sarcoma · condition mapped ONTOLOGY_EXACT · 53 trials mapped (21 active)	—	—	Undifferentiated Pleomorphic Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03307616Phase 2 · active not recruiting Nivolumab With and Without Ipilimumab and Radiation Therapy in Treating Patients With Recurrent or Resectable Undifferentiated Pleomorphic Sarcoma or Dedifferentiated Liposarcoma Before Surgery · condition mapped CURATED_BROADER · 53 trials mapped (21 active)	—	—	Undifferentiated Pleomorphic Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07817095Phase 2 · not yet recruiting SBRT Combined With Reduced-Dose Anthracycline Chemotherapy and Toripalimab as Neoadjuvant Therapy for Localized High-Risk Undifferentiated Pleomorphic Sarcoma · condition mapped ONTOLOGY_EXACT · 53 trials mapped (21 active)	—	—	Undifferentiated Pleomorphic Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05711615Phase 1 · recruiting Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma · condition mapped CURATED_BROADER · 53 trials mapped (21 active)	—	—	Undifferentiated Pleomorphic Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05827614Phase 1 · terminated Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene Amplifications · condition mapped ONTOLOGY_EXACT · 53 trials mapped (21 active)	—	—	Undifferentiated Pleomorphic Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06239272Phase 1/Phase 2 · recruiting NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) · condition mapped ONTOLOGY_EXACT · 53 trials mapped (21 active)	—	—	Undifferentiated Pleomorphic Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07741877Phase 2 · not yet recruiting A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Soft Tissue Sarcoma · condition mapped ONTOLOGY_EXACT · 53 trials mapped (21 active)	—	—	Undifferentiated Pleomorphic Sarcoma	1	Observed	clinicaltrials	graph →

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