Renal Pelvis and Ureter Urothelial Carcinoma

subtype

Identifier: CI-CAN-00006582
Entity page: /cancer/renal-pelvis-and-ureter-urothelial-carcinoma ↗
Edges: 91

Neighbours: 9 genes15 drugs10 trials
Drawn: 34 of 34 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Renal Pelvis and Ureter Urothelial Carcinoma altered in cohorts of …ALTERED_INderived9 of 9
← altered in cohorts of	FGFR3 55 / 119 cases (46 %) · ssm · utuc_msk_2019 · largest of 3 cohorts	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	3	Observed	cbioportal	graph →
← altered in cohorts of	KMT2D 41 / 119 cases (34 %) · ssm · utuc_msk_2019 · largest of 3 cohorts

Renal Pelvis and Ureter Urothelial Carcinoma investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 30show all (up to 200)
→ investigated in trials for	Pembrolizumabmonoclonal antibody 11 trials (8 active) · roll-up of the cancer and its descendants	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	11	Observed	clinicaltrials	graph →
→ investigated in trials for	Enfortumab Vedotinadc 7 trials (6 active) · roll-up of the cancer and its descendants	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal antibody 7 trials (6 active) · roll-up of the cancer and its descendants	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Gemcitabinesmall molecule 6 trials (1 active) · roll-up of the cancer and its descendants	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Atezolizumabmonoclonal antibody 4 trials (2 active) · roll-up of the cancer and its descendants	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Avelumabmonoclonal antibody 4 trials (3 active) · roll-up of the cancer and its descendants	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Cisplatinsmall molecule 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Durvalumabmonoclonal antibody 3 trials (3 active) · roll-up of the cancer and its descendants	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Cabozantinibsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Disitamab Vedotinadc 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Erdafitinibsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Eribulinsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Ipilimumabmonoclonal antibody 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Toripalimabmonoclonal antibody 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Aldesleukinother 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	1	Observed	clinicaltrials	graph →

Renal Pelvis and Ureter Urothelial Carcinoma investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 30show all (up to 200)

→ investigated in trials for

Pembrolizumabmonoclonal antibody

11 trials (8 active) · roll-up of the cancer and its descendants

—

Renal Pelvis and Ureter Urothelial Carcinoma

Observed

Renal Pelvis and Ureter Urothelial Carcinoma studied in …STUDIED_INderived10 of 52show all (up to 200)
→ studied in	NCT04628767Phase 2/Phase 3 · recruiting Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer · condition mapped ONTOLOGY_EXACT · 52 trials mapped (36 active)	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05987241Phase 2/Phase 3 · recruiting Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study · condition mapped ONTOLOGY_EXACT · 52 trials mapped (36 active)	—	—	Muscle Invasive Renal Pelvis Urothelial Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04963153Phase 1 · active not recruiting Testing Combination Erdafitinib and Enfortumab Vedotin in Metastatic Bladder Cancer After Treatment With Chemotherapy and Immunotherapy · condition mapped CURATED_BROADER · 52 trials mapped (36 active)	—	—	Renal Pelvis Urothelial Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07667335Phase 1/Phase 2 · recruiting Enfortumab Vedotin, Pembrolizumab and Quemliclustat for the Treatment of Unresectable Locally Advanced and Metastatic Urothelial Cancer · condition mapped CURATED_BROADER · 52 trials mapped (36 active)	—	—	Renal Pelvis Urothelial Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04940299Phase 2 · active not recruiting Tocilizumab, Ipilimumab, and Nivolumab for the Treatment of Advanced Melanoma, Non-Small Cell Lung Cancer, or Urothelial Carcinoma · condition mapped CURATED_BROADER · 52 trials mapped (36 active)	—	—	Renal Pelvis Urothelial Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05494411available Named Patient Program for Mitomycin for Pyelocalyceal Solution · condition mapped ALIAS · 52 trials mapped (36 active)	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02812420early Phase 1 · active not recruiting Durvalumab and Tremelimumab in Treating Patients With Muscle-Invasive, High-Risk Urothelial Cancer That Cannot Be Treated With Cisplatin-Based Therapy Before Surgery · condition mapped ALIAS · 52 trials mapped (36 active)	—	—	Invasive Renal Pelvis Sarcomatoid Urothelial Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02496208Phase 1 · active not recruiting Cabozantinib S-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors · condition mapped ONTOLOGY_EXACT · 52 trials mapped (36 active)	—	—	Renal Pelvis Urothelial Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06040762NA · recruiting A Home-Based Prehabilitation Exercise Intervention for Improving Physical Function in Patients With Bladder Cancer and Upper Tract Urothelial Cancer, Get Moving Trial · condition mapped ONTOLOGY_EXACT · 52 trials mapped (36 active)	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06774131Phase 3 · recruiting A Phase 3 Single-arm Study of UGN-104 for the Treatment of Low-grade Upper Tract Urothelial Cancer · condition mapped ALIAS · 52 trials mapped (36 active)	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	1	Observed	clinicaltrials	graph →

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