Pancreatic Neuroendocrine Neoplasm

subtype

Identifier: CI-CAN-00001357
Entity page: /cancer/pancreatic-neuroendocrine-neoplasm ↗
Edges: 231

Neighbours: 3 genes15 drugs10 trials
Drawn: 28 of 28 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Pancreatic Neuroendocrine Neoplasm altered in cohorts of …ALTERED_INderived3 of 3
← altered in cohorts of	MEN1 36 / 98 cases (37 %) · ssm · panet_arcnet_2017 · largest of 2 cohorts	—	—	Pancreatic Neuroendocrine Tumor	2	Observed	cbioportal	graph →
← altered in cohorts of	DAXX 22 / 98 cases (22 %) · ssm · panet_arcnet_2017 · largest of 2 cohorts	—

Pancreatic Neuroendocrine Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 53show all (up to 200)
→ investigated in trials for	Everolimussmall molecule 17 trials (2 active) · roll-up of the cancer and its descendants	—	—	Pancreatic Neuroendocrine Neoplasm	17	Observed	clinicaltrials	graph →
→ investigated in trials for	Temozolomidesmall molecule 10 trials (3 active) · roll-up of the cancer and its descendants	—	—	Pancreatic Neuroendocrine Neoplasm	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Sunitinibsmall molecule 9 trials (2 active) · roll-up of the cancer and its descendants	—	—	Pancreatic Neuroendocrine Neoplasm	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Capecitabinesmall molecule 8 trials (3 active) · roll-up of the cancer and its descendants	—	—	Pancreatic Neuroendocrine Neoplasm	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal antibody 5 trials (1 active) · roll-up of the cancer and its descendants	—	—	Pancreatic Neuroendocrine Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Lutetium (177lu) Oxodotreotideother 4 trials (4 active) · roll-up of the cancer and its descendants	—	—	Pancreatic Neuroendocrine Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Cabozantinibsmall molecule 3 trials (2 active) · roll-up of the cancer and its descendants	—	—	Pancreatic Neuroendocrine Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Fluorouracilsmall molecule 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pancreatic Neuroendocrine Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Leucovorinsmall molecule 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pancreatic Neuroendocrine Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Temsirolimussmall molecule 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pancreatic Neuroendocrine Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Afliberceptother 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pancreatic Neuroendocrine Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Atezolizumabmonoclonal antibody 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Pancreatic Neuroendocrine Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Cisplatinsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Pancreatic Neuroendocrine Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Dactolisibsmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Pancreatic Neuroendocrine Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal antibody 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Pancreatic Neuroendocrine Neoplasm	2	Observed	clinicaltrials	graph →

Pancreatic Neuroendocrine Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 53show all (up to 200)

→ investigated in trials for

Everolimussmall molecule

17 trials (2 active) · roll-up of the cancer and its descendants

—

Pancreatic Neuroendocrine Neoplasm

Observed

Pancreatic Neuroendocrine Neoplasm studied in …STUDIED_INderived10 of 175show all (up to 200)
→ studied in	NCT01824875Phase 2 · completed Temozolomide With or Without Capecitabine in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors · condition mapped ALIAS · 175 trials mapped (48 active)	—	—	Pancreatic Glucagonoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06943755Phase 2/Phase 3 · recruiting Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors · condition mapped ONTOLOGY_EXACT · 175 trials mapped (48 active)	—	—	Pancreatic Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT00001276recruiting Diagnosing and Treating Low Blood Sugar Levels · condition mapped ALIAS · 175 trials mapped (48 active)	—	—	Pancreatic Insulinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04924075Phase 2 · recruiting Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015) · condition mapped ONTOLOGY_EXACT · 175 trials mapped (48 active)	—	—	Pancreatic Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT03967951completed CT Radiomic Features of Pancreatic Neuroendocrine Neoplasms · condition mapped ONTOLOGY_EXACT · 175 trials mapped (48 active)	—	—	Pancreatic Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT03375320Phase 3 · active not recruiting Testing Cabozantinib in Patients With Advanced Pancreatic Neuroendocrine and Carcinoid Tumors · condition mapped CURATED_BROADER · 175 trials mapped (48 active)	—	—	Pancreatic Neuroendocrine Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07817225active not recruiting Optimizing Risk Assessment Through cfDNA in Pancreatic Neuroendocrine Tumors for Clinical Evaluation · condition mapped ONTOLOGY_EXACT · 175 trials mapped (48 active)	—	—	Pancreatic Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT07087054Phase 3 · recruiting Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine Regimen · condition mapped ALIAS · 175 trials mapped (48 active)	—	—	Pancreatic Serotonin-Producing Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT07165132Phase 1 · recruiting Study of RYZ401 in Subjects With Solid Tumors Expressing SSTRs. · condition mapped ALIAS · 175 trials mapped (48 active)	—	—	Pancreatic Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT03074513Phase 2 · active not recruiting Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors · condition mapped ONTOLOGY_EXACT · 175 trials mapped (48 active)	—	—	Pancreatic Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →

Radial view

Every edge, grouped by relationship

Strongest chains