MSI-H Colorectal Carcinoma

subtype

Identifier: CI-CAN-00009009
Entity page: /cancer/msi-h-colorectal-carcinoma ↗
Edges: 26

Neighbours: 12 drugs10 trials
Drawn: 22 of 22 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
MSI-H Colorectal Carcinoma approved for …APPROVED_FOR2 of 2
← approved for	Nivolumabmonoclonal_antibody	supports	EMA indication text	MSI-H Colorectal Carcinoma	1	Regulatory	ema	graph →
← approved for	Ipilimumabmonoclonal_antibody	supports	EMA indication text

MSI-H Colorectal Carcinoma investigated in trials for …INVESTIGATED_IN_TRIALSderived10 of 10
→ investigated in trials for	Pembrolizumabmonoclonal antibody 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	MSI-H Colorectal Carcinoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Tislelizumabmonoclonal antibody 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	MSI-H Colorectal Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Capecitabinesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Docetaxelsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Ipilimumab/Nivolumab Regimen 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Leucovorinsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Niraparibsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Oxaliplatinsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Panitumumabmonoclonal antibody 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Regorafenibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →

MSI-H Colorectal Carcinoma investigated in trials for …INVESTIGATED_IN_TRIALSderived10 of 10

→ investigated in trials for

Pembrolizumabmonoclonal antibody

3 trials (0 active) · roll-up of the cancer and its descendants

—

MSI-H Colorectal Carcinoma studied in …STUDIED_INderived10 of 14show all (up to 200)
→ studied in	NCT05714553Phase 1/Phase 2 · terminated NUC-3373 in Combination With Other Agents in Patients With Advanced Solid Tumours · condition mapped ALIAS · 14 trials mapped (6 active)	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05520099active not recruiting Observational Basket Trial to Collect Tissue to Develop and Train a Live Tumor Diagnostic Platform (ELEPHAS-02) · condition mapped ALIAS · 14 trials mapped (6 active)	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07327489recruiting Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05) · condition mapped ALIAS · 14 trials mapped (6 active)	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06006923Phase 2 · terminated Regorafenib in Combination With Pembrolizumab or Pembrolizumab for MSI-H Colorectal Cancer · condition mapped ALIAS · 14 trials mapped (6 active)	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03983993Phase 2 · active not recruiting Niraparib and Panitumumab in Patients With Advanced or Metastatic Colorectal Cancer · condition mapped ALIAS · 14 trials mapped (6 active)	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06414304completed Dynamics of MSI and Genomic Profile of Colorectal Cancer In the Course of Immune Checkpoint Inhibitor Therapy · condition mapped ALIAS · 14 trials mapped (6 active)	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04730544Phase 2 · active not recruiting Two Combination Treatment Regimens of Nivolumab and Ipilimumab in Patients With dMMR and / or MSI mCRC. · condition mapped ALIAS · 14 trials mapped (6 active)	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04802876Phase 2 · active not recruiting Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients with PD1-high MRNA Expressing Tumors · condition mapped ALIAS · 14 trials mapped (6 active)	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04301557Phase 2 · unknown PD1 Antibody Toripalimab and Chemoradiotherapy for dMMR/MSI-H Locally Advanced Colorectal Cancer · condition mapped ALIAS · 14 trials mapped (6 active)	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04244552Phase 1 · terminated A Phase 1b Trial of ATRC-101 in Adults With Advanced Solid Malignancies · condition mapped ALIAS · 14 trials mapped (6 active)	—	—	MSI-H Colorectal Carcinoma	1	Observed	clinicaltrials	graph →

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