| Meningeal Carcinomatosis studied in …STUDIED_INderived59 of 59show fewer |
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| → studied in | NCT06462222Phase 1/Phase 2 · active not recruiting Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07833657Phase 2 · not yet recruiting Combined Intrathecal and Systemic Therapy With Trastuzumab Rezetecan for Leptomeningeal Metastases · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06762080Phase 1/Phase 2 · active not recruiting Intrathecal Combination of Programmed Death-1 (PD-1)/Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Bispecific Antibody and Pemetrexed for Leptomeningeal Metastasis · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06809530Phase 1/Phase 2 · active not recruiting Intrathecal Dual Checkpoint Inhibitor (PD-1 and CTLA-4) in Combination With Pemetrexed for Leptomeningeal Metastasis · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07778940Phase 2 · not yet recruiting Thiotepa Administration Via Ommaya Reservoir for Leptomeningeal Metastases in Non-Small Cell Lung Cancer Resistant to EGFR-TKI. · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06812871Phase 2 · completed High-dose Furmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Meningeal Metastasis · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05184816Phase 1 · recruiting A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07702305Phase 1 · not yet recruiting Safety and Efficacy of Intrathecal Sacituzumab Tirumotecan for Leptomeningeal Metastasis in EGFR-TKI-Resistant Non-Small Cell Lung Cancer · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07674693Phase 1 · not yet recruiting Phase 1 Study of WBRT or PCSI With REYOBIQ for Leptomeningeal Metastases · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07361705Phase 1 · recruiting Zorifertinib With Osimertinib for NSCLC With Meningeal Progression · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06431685Phase 1 · recruiting Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07551414Phase 2 · not yet recruiting Zorifertinib Plus Intra-Ommaya CSF Chemotherapy for Leptomeningeal Progression in NSCLC After Third-Generation EGFR-TKI · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07348965NA · recruiting Pulsatile High-dose Furmonertinib in EGFR-mutant NSCLC With Leptomeningeal Metastasis · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06984523NA · active not recruiting Study of Craniospinal Irradiation With Linac Based Volumetric Modulated Arc Therapy (VMAT) for Patients With Leptomeningeal Metastasis · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05805631Phase 2 · recruiting Intrathecal Pemetrexed for Leptomeningeal Metastasis in EGFR-Mutant NSCLC · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04661384Phase 1 · active not recruiting Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04343573Phase 2 · completed Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06592092NA · completed Clinical Study of QH104 Cell Injection for the Treatment of Meningeal Metastases of B7H3+ Solid Tumors · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07264569Phase 1/Phase 2 · recruiting Evaluate the Safety, Tolerability, Biodistribution Characteristics and Preliminary Efficacy of BioTTT001 · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01373710Phase 1/Phase 2 · completed Intrathecal Trastuzumab Administration in Metastatic Breast Cancer Patients Developing Carcinomatous Meningitis · condition mapped ALIAS · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02939300Phase 2 · completed Ipilimumab and Nivolumab in Leptomeningeal Metastases · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05598853Phase 1 · active not recruiting Intrathecal Double Checkpoint Inhibition · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06304441NA · recruiting Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT07092202Phase 4 · recruiting Firmonertinib Combined With Intrathecal Injection for the Treatment of EGFR Mutant NSCLC With Leptomeningeal Metastases · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04729348Phase 2 · terminated Pembrolizumab And Lenvatinib In Leptomeningeal Metastases · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00527410Phase 1 · terminated A Safety Study of RTA 744 in Recurrent, Progressive or Refractory Neoplastic Meningitis · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06809517Phase 1/Phase 2 · recruiting Intrathecal PD-1/VEGF Bispecific Antibody Plus Pemetrexed for Leptomeningeal Metastasis · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06971406Phase 2 · not yet recruiting High-Dose Firmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed in the Treatment of EGFR-Mutated Non-Small Cell Lung Cancer With Leptomeningeal Metastasis · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05289908Phase 1/Phase 2 · completed Intrathecal Pemetrexed for Leptomeningeal Metastasis · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06718972recruiting A Real-world Study on the Treatment of Non-small Cell Lung Cancer With Leptomeningeal Metastasis in China · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05746754NA · recruiting Proton Cranio-spinal Irradiation for Leptomeningeal Metastasis · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06901817Phase 2 · recruiting A Study of the Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatment of Refractory Non-squamous Non-small Cell Lung Cancer with Leptomeningeal Metastases · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05034497Phase 1 · active not recruiting Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06643000NA · recruiting Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal Metastasis · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06861218Phase 2 · not yet recruiting Cerebrospinal Fluid Cytology-guided Intrathecal Chemo-holiday Therapy for EGFR-positive NSCLC Leptomeningeal Metastases · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06766591NA · not yet recruiting Ivonescimab Combined With Chemotherapy for the Treatment of Leptomeningeal Metastases Failed to EGFR-TKIs · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06705049enrolling by invitation Retrospective Study on Leptomeningeal Metastasis of Solid Tumors · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06441045Phase 2 · not yet recruiting Double Dose of Third-generation EGFR-TKI Plus Intrathecal Pemetrexed Versus Double Dose of Third-generation EGFR-TKI in Patients With LM Progression Following the Treatment of Routine Dose of Third-generation EGFR-TKI · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03520504Phase 1 · completed Study of Proton Radiation to the Brain and Spinal Cord for Patients With Leptomeningeal Metastases · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05305885NA · unknown Intra-pemetrexed Alone or Combined With Concurrent Radiotherapy for Leptomeningeal Metastasis · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04315246Phase 1/Phase 2 · withdrawn 177Lu-DTPA-Omburtamab Radioimmunotherapy for Leptomeningeal Metastasis From Solid Tumors (Breast, NSCLC, Malignant Melanoma) · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05385185Phase 2 · unknown Clinical Observation of ICI Combined With Recombinant Human Endostatin on Leptomeningeal Metastasis of Lung Cancer · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04944069NA · unknown Almonertinib With Bevacizumab for EGFR-Mutant NSCLC Patients With Leptomeningeal Metastasis · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01713699NA · completed Circulating Tumor Cells and Cytology in Cerebrospinal Fluid of Patients Clinically Suspected for Leptomeningeal Metastases · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02071056completed Circulating Tumor DNA in Cerebrospinal Fluid as an Early Biomarker of Leptomeningeal Metastasis (LM) · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04425681Phase 2 · unknown Osimertinib With Bevacizumab for Leptomeningeal Metastasis From EGFR-mutation Non-Small Cell Lung Cancer · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04356118Phase 4 · unknown Efficacy and Safety of Recombinant Human Endostatin in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04356222Phase 4 · unknown Efficacy and Safety of Durvalumab in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03507244Phase 1/Phase 2 · completed Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04178343NA · completed Tomotherapy for Leptomeningeal Metastases · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04148898Phase 2 · unknown Osimertinib With or Without Bevacizumab for EGFR- Mutant Non-small Cell Lung Cancer With Leptomeningeal Metastasis · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03082144Phase 2 · completed Concurrent Involved-field Radiotherapy and Intrathecal Chemotherapy for Leptomeningeal Metastases From Solid Tumors · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03101579Phase 1 · completed Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02607605unknown A Prospective, Observational Trial on the Diagnostic and Prognostic of LM · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02590510Phase 4 · unknown Different Dose of Methotrexate for the Treatment of Meningeal Carcinomatosis · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02803619unknown A Multi-center Prospective Observational Biomarker Study on EGFRm+ Non-small Cell Lung Cancer Patients With Leptomeningeal Metastasis · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01818713Phase 2 · unknown Clinical and Pharmacological Study With 2B3-101 in Patients With Breast Cancer and Leptomeningeal Metastases · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00005812Phase 2 · terminated Temozolomide in Treating Patients With Leptomeningeal Metastases From a Solid Tumor or Lymphoma · condition mapped PROBABILISTIC · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01438021NA · withdrawn Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease · condition mapped ONTOLOGY_EXACT · 59 trials mapped (30 active) | — | — | Meningeal Carcinomatosis | 1 | Observed | clinicaltrials | graph → |