Malignant Gallbladder Neoplasm

cancer

Identifier: CI-CAN-00003159
Entity page: /cancer/malignant-gallbladder-neoplasm ↗
Edges: 269

Neighbours: 9 genes15 drugs10 trials
Drawn: 34 of 34 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Malignant Gallbladder Neoplasm altered in cohorts of …ALTERED_INderived9 of 9
← altered in cohorts of	TP53 154 / 244 cases (63 %) · ssm · gbc_mskcc_2022 · largest of 2 cohorts	—	—	Gallbladder Carcinoma	2	Observed	cbioportal	graph →
← altered in cohorts of	SMAD4 52 / 244 cases (21 %) · ssm · gbc_mskcc_2022 · largest of 2 cohorts	—	—

Malignant Gallbladder Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 59show all (up to 200)
→ investigated in trials for	Gemcitabinesmall molecule 43 trials (7 active) · roll-up of the cancer and its descendants	—	—	Malignant Gallbladder Neoplasm	43	Observed	clinicaltrials	graph →
→ investigated in trials for	Cisplatinsmall molecule 25 trials (7 active) · roll-up of the cancer and its descendants	—	—	Malignant Gallbladder Neoplasm	25	Observed	clinicaltrials	graph →
→ investigated in trials for	Oxaliplatinsmall molecule 18 trials (3 active) · roll-up of the cancer and its descendants	—	—	Malignant Gallbladder Neoplasm	18	Observed	clinicaltrials	graph →
→ investigated in trials for	Capecitabinesmall molecule 14 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Gallbladder Neoplasm	14	Observed	clinicaltrials	graph →
→ investigated in trials for	Fluorouracilsmall molecule 13 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Gallbladder Neoplasm	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Leucovorinsmall molecule 10 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Gallbladder Neoplasm	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Irinotecansmall molecule 7 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Gallbladder Neoplasm	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Erlotinib Hydrochloridesmall molecule 6 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Gallbladder Neoplasm	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Nab-paclitaxel 5 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Gallbladder Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Pembrolizumabmonoclonal antibody 5 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Gallbladder Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Atezolizumabmonoclonal antibody 4 trials (2 active) · roll-up of the cancer and its descendants	—	—	Malignant Gallbladder Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal antibody 4 trials (1 active) · roll-up of the cancer and its descendants	—	—	Malignant Gallbladder Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Durvalumabmonoclonal antibody 4 trials (3 active) · roll-up of the cancer and its descendants	—	—	Malignant Gallbladder Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Carboplatinsmall molecule 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Gallbladder Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Everolimussmall molecule 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Malignant Gallbladder Neoplasm	3	Observed	clinicaltrials	graph →

Malignant Gallbladder Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 59show all (up to 200)

→ investigated in trials for

Gemcitabinesmall molecule

43 trials (7 active) · roll-up of the cancer and its descendants

—

Malignant Gallbladder Neoplasm

Observed

Malignant Gallbladder Neoplasm studied in …STUDIED_INderived10 of 201show all (up to 200)
→ studied in	NCT05712356Phase 2 · completed A Study of LSTA1 When Added to Standard of Care Versus Standard of Care Alone in Patients With Advanced Solid Tumors · condition mapped CURATED_EXACT · 201 trials mapped (42 active)	—	—	Malignant Gallbladder Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02293954NA · active not recruiting Copper Cu 64 Anti-CEA Monoclonal Antibody M5A PET in Diagnosing Patients With CEA Positive Cancer · condition mapped CURATED_EXACT · 201 trials mapped (42 active)	—	—	Malignant Gallbladder Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07146646Phase 2 · recruiting Trifluridine/Tipiracil + Oxaliplatin in Participants With Advanced or Metastatic Biliary Tract Cancer · condition mapped CURATED_EXACT · 201 trials mapped (42 active)	—	—	Malignant Gallbladder Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06531408active not recruiting Predicting Incidental Gallbladder Cancer · condition mapped CURATED_EXACT · 201 trials mapped (42 active)	—	—	Malignant Gallbladder Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04559139Phase 2/Phase 3 · active not recruiting Comparison of Chemotherapy Before and After Surgery Versus After Surgery Alone for the Treatment of Gallbladder Cancer · condition mapped CURATED_BROADER · 201 trials mapped (42 active)	—	—	Malignant Gallbladder Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05482516Phase 3 · recruiting Evaluating Novel Therapies in ctDNA Positive GI Cancers · condition mapped ONTOLOGY_EXACT · 201 trials mapped (42 active)	—	—	Gallbladder Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07780838Phase 2 · recruiting Alternating Chemo-immunotherapy and FGFR Inhibitor for FGFR-positive Biliary or Cholangiocarcinoma · condition mapped CURATED_BROADER · 201 trials mapped (42 active)	—	—	Malignant Gallbladder Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07282912Phase 2 · recruiting Trial Comparing Standard of Care Therapy With and Without Sequential Cytoreductive Intervention for Patients With Metastatic Foregut Adenocarcinoma and Undetectable Circulating Tumor-Deoxyribose Nucleic Acid (ctDNA) Levels · condition mapped ONTOLOGY_EXACT · 201 trials mapped (42 active)	—	—	Gallbladder Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07793253Phase 2 · not yet recruiting Phase 2 Study of Daraxonrasib in Recurrent KRAS-Mutant Biliary Tract Cancer · condition mapped ONTOLOGY_EXACT · 201 trials mapped (42 active)	—	—	Gallbladder Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04068194Phase 1/Phase 2 · active not recruiting Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies · condition mapped CURATED_BROADER · 201 trials mapped (42 active)	—	—	Malignant Gallbladder Neoplasm	1	Observed	clinicaltrials	graph →

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