Leptomeningeal Neoplasm — knowledge graph · CancerIndex

Knowledge graph · Cancer

Leptomeningeal Neoplasm

subtype

Identifier: CI-CAN-00003024
Entity page: /cancer/leptomeningeal-neoplasm ↗
Edges: 47

Neighbours: 15 drugs10 trials
Drawn: 25 of 25 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Leptomeningeal Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 15
→ investigated in trials for	Trastuzumabmonoclonal antibody 4 trials (3 active) · roll-up of the cancer and its descendants	—	—	Leptomeningeal Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal antibody 3 trials (3 active) · roll-up of the cancer and its descendants

Leptomeningeal Neoplasm studied in …STUDIED_INderived10 of 32show all (up to 200)
→ studied in	NCT05809752Phase 1 · active not recruiting A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV) · condition mapped ALIAS · 32 trials mapped (22 active)	—	—	Leptomeningeal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04988009recruiting Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology · condition mapped ONTOLOGY_EXACT · 32 trials mapped (22 active)	—	—	Leptomeningeal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07814352Phase 1 · recruiting A Study of SX-682 in Combination With Proton Craniospinal Irradiation (pCSI) in People With Leptomeningeal Disease · condition mapped ALIAS · 32 trials mapped (22 active)	—	—	Leptomeningeal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07390539Phase 1 · recruiting B7-H3.CD28Z.CART in CNS Neoplasms · condition mapped ALIAS · 32 trials mapped (22 active)	—	—	Leptomeningeal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT03025256Phase 1 · active not recruiting Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease · condition mapped ONTOLOGY_EXACT · 32 trials mapped (22 active)	—	—	Leptomeningeal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07414979Phase 1 · not yet recruiting Phase 1 Study Of Intrathecal Cellular Adoptive Immunotherapy Using Autologous CD8+ Antigen-Specific T Cells For Patients With Leptomeningeal Melanoma · condition mapped ALIAS · 32 trials mapped (22 active)	—	—	Meningeal Melanoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07751744Phase 1/Phase 2 · not yet recruiting Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma · condition mapped ALIAS · 32 trials mapped (22 active)	—	—	Leptomeningeal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07476781NA · recruiting Exploring the Feasibility of Cerebrospinal Fluid (CSF) and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and Primary Central Nervous System (CNS) Tumours: A Pilot Study · condition mapped ALIAS · 32 trials mapped (22 active)	—	—	Leptomeningeal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT03423628Phase 1 · active not recruiting A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer · condition mapped ALIAS · 32 trials mapped (22 active)	—	—	Leptomeningeal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07694986Phase 2 · recruiting Trial of Therapies With IT cDC1s Combined w/ IT Trastuzamab for Her+ or IT Nivolumab for Her- BC LMD · condition mapped ALIAS · 32 trials mapped (22 active)	—	—	Leptomeningeal Neoplasm	1	Observed	clinicaltrials	graph →