High Grade Sarcoma

subtype

Identifier: CI-CAN-00000994
Entity page: /cancer/high-grade-sarcoma ↗
Edges: 41

Neighbours: 23 drugs10 trials
Drawn: 33 of 33 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
High Grade Sarcoma approved for …APPROVED_FORderived5 of 5
← approved for	Leuprolideother FDA (US) · approved · 2020-05-01 · FENSOLVI ® is indicated for the treatment of pediatric patients 2 years of age and older with central precocious puberty (CPP). FENSOLVI is…	—	approved	Conventional Osteosarcoma	1	Regulatory	openfda	graph →
← approved for	Triptorelin

High Grade Sarcoma investigated in trials for …INVESTIGATED_IN_TRIALSderived19 of 19show fewer
→ investigated in trials for	Docetaxelsmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Doxorubicinsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Gemcitabinesmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Atezolizumabmonoclonal antibody 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Avelumabmonoclonal antibody 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Cabozantinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Cisplatinsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Ifosfamidesmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Irinotecansmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Ivosidenibsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Methotrexatesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Pazopanibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Regorafenibsmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Sapanisertibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Valproic Acidsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Vimseltinibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Vincristinesmall molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →

High Grade Sarcoma investigated in trials for …INVESTIGATED_IN_TRIALSderived19 of 19show fewer

→ investigated in trials for

Docetaxelsmall molecule

2 trials (0 active) · roll-up of the cancer and its descendants

—

High Grade Sarcoma

Observed

High Grade Sarcoma studied in …STUDIED_INderived10 of 17show all (up to 200)
→ studied in	NCT05691478Phase 2/Phase 3 · suspended A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma · condition mapped ONTOLOGY_EXACT · 17 trials mapped (7 active)	—	—	High Grade Osteosarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06820957Phase 2/Phase 3 · active not recruiting Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body · condition mapped CURATED_BROADER · 17 trials mapped (7 active)	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04458922Phase 2 · active not recruiting Testing Atezolizumab in People 2-17 Years Old With Clear Cell Sarcoma or Advanced Chondrosarcoma · condition mapped ONTOLOGY_EXACT · 17 trials mapped (7 active)	—	—	Central Chondrosarcoma, Grade 3	1	Observed	clinicaltrials	graph →
→ studied in	NCT07650656Phase 2 · recruiting Fluorescence-Guided Surgical Resection for Reducing Unexpected Positive Margins in Patients With Sarcoma, SarcoSIGHT Trial · condition mapped ONTOLOGY_EXACT · 17 trials mapped (7 active)	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06068075NA · active not recruiting Liquid Biopsy in Ewing Sarcoma and Osteosarcoma as a Prognostic And Response Diagnostic: LEOPARD · condition mapped ONTOLOGY_EXACT · 17 trials mapped (7 active)	—	—	High Grade Osteosarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04278781Phase 2 · active not recruiting AG-120 in People With IDH1 Mutant Chondrosarcoma · condition mapped ONTOLOGY_EXACT · 17 trials mapped (7 active)	—	—	Chondrosarcoma, Grade 3	1	Observed	clinicaltrials	graph →
→ studied in	NCT05301283Phase 2 · recruiting Habitat Escalated Adaptive Therapy (HEAT), With Neoadjuvant Radiation for Soft Tissue Sarcoma · condition mapped ONTOLOGY_EXACT · 17 trials mapped (7 active)	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04242238Phase 1 · completed Study of DCC-3014 in Combination With Avelumab in Patients With Advanced or Metastatic Sarcomas · condition mapped ONTOLOGY_EXACT · 17 trials mapped (7 active)	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06535997completed Descriptive Cohort of French Patients Treated With Carbonetherapy Since October 2010 Outside PHRC-ETOILE · condition mapped ONTOLOGY_EXACT · 17 trials mapped (7 active)	—	—	Chondrosarcoma, Grade 3	1	Observed	clinicaltrials	graph →
→ studied in	NCT03951571Phase 2 · completed Efficacy and Safety of Anlotinib in Adjuvant Therapy for High-grade Soft Tissue Sarcoma · condition mapped ONTOLOGY_EXACT · 17 trials mapped (7 active)	—	—	High Grade Sarcoma	1	Observed	clinicaltrials	graph →

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