Erdheim-Chester Disease — knowledge graph · CancerIndex

Knowledge graph · Cancer

Erdheim-Chester Disease

hematologic malignancy

Identifier: CI-CAN-00000850
Entity page: /cancer/erdheim-chester-disease ↗
Edges: 19

Neighbours: 9 drugs10 trials
Drawn: 19 of 19 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Erdheim-Chester Disease investigated in trials for …INVESTIGATED_IN_TRIALSderived9 of 9
→ investigated in trials for	Cobimetinibsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Erdheim-Chester Disease	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal antibody 1 trials (0 active) · roll-up of the cancer and its descendants

Erdheim-Chester Disease studied in …STUDIED_INderived10 of 10
→ studied in	NCT07440290Phase 2/Phase 3 · recruiting DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers. · condition mapped ONTOLOGY_EXACT · 10 trials mapped (8 active)	—	—	Erdheim-Chester Disease	1	Observed	clinicaltrials	graph →
→ studied in	NCT02523040Phase 2 · active not recruiting Lenalidomide for Adult Histiocyte Disorders · condition mapped PROBABILISTIC · 10 trials mapped (8 active)	—	—	Erdheim-Chester Disease	1	Observed	clinicaltrials	graph →
→ studied in	NCT05915208recruiting Histiocytic Disorder Follow-up Study · condition mapped ONTOLOGY_EXACT · 10 trials mapped (8 active)	—	—	Erdheim-Chester Disease	1	Observed	clinicaltrials	graph →
→ studied in	NCT01552434Phase 1 · terminated Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease · condition mapped ONTOLOGY_EXACT · 10 trials mapped (8 active)	—	—	Erdheim-Chester Disease	1	Observed	clinicaltrials	graph →
→ studied in	NCT05093335early Phase 1 · recruiting In-Human CXCR4 Imaging of Hematologic and Solid Tumors Using [68Ga]-Pentixafor-PET · condition mapped ONTOLOGY_EXACT · 10 trials mapped (8 active)	—	—	Erdheim-Chester Disease	1	Observed	clinicaltrials	graph →
→ studied in	NCT05768178Phase 2/Phase 3 · recruiting DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers. · condition mapped ONTOLOGY_EXACT · 10 trials mapped (8 active)	—	—	Erdheim-Chester Disease	1	Observed	clinicaltrials	graph →
→ studied in	NCT06712810Phase 1 · recruiting Q702 for the Treatment of Patients With Hematologic Malignancies · condition mapped CURATED_BROADER · 10 trials mapped (8 active)	—	—	Erdheim-Chester Disease	1	Observed	clinicaltrials	graph →
→ studied in	NCT04079179Phase 2 · recruiting Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders · condition mapped ONTOLOGY_EXACT · 10 trials mapped (8 active)	—	—	Erdheim-Chester Disease	1	Observed	clinicaltrials	graph →
→ studied in	NCT02285582recruiting International Rare Histiocytic Disorders Registry (IRHDR) · condition mapped ONTOLOGY_EXACT · 10 trials mapped (8 active)	—	—	Erdheim-Chester Disease	1	Observed	clinicaltrials	graph →
→ studied in	NCT04198818Phase 1/Phase 2 · terminated A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of HH2710 in Patient With Advanced Tumors · condition mapped ONTOLOGY_EXACT · 10 trials mapped (8 active)	—	—	Erdheim-Chester Disease	1	Observed	clinicaltrials	graph →