Carcinoma In Situ

histology

Identifier: CI-CAN-00000635
Entity page: /cancer/carcinoma-in-situ ↗
Edges: 312

Neighbours: 19 drugs10 trials
Drawn: 29 of 29 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Carcinoma In Situ investigated for …INVESTIGATED_FOR6 of 6
← investigated for	Valrubicinsmall_molecule	unknown	3	Carcinoma In Situ	1	Curated	chembl	graph →
← investigated for	Mitomycinsmall_molecule	unknown	3

Carcinoma In Situ investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 32show all (up to 200)
→ investigated in trials for	Tamoxifensmall molecule 14 trials (6 active) · roll-up of the cancer and its descendants	—	—	Carcinoma In Situ	14	Observed	clinicaltrials	graph →
→ investigated in trials for	Letrozolesmall molecule 4 trials (1 active) · roll-up of the cancer and its descendants	—	—	Carcinoma In Situ	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Afimoxifenesmall molecule 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Carcinoma In Situ	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Anastrozolesmall molecule 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Carcinoma In Situ	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Gemcitabinesmall molecule 3 trials (2 active) · roll-up of the cancer and its descendants	—	—	Carcinoma In Situ	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Exemestanesmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Carcinoma In Situ	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Hormone Therapy 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Carcinoma In Situ	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Lapatinibsmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Carcinoma In Situ	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Metforminsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Carcinoma In Situ	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Mitomycinsmall_molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Carcinoma In Situ	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Pembrolizumabmonoclonal_antibody 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Carcinoma In Situ	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Trastuzumabmonoclonal antibody 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Carcinoma In Situ	2	Observed	clinicaltrials	graph →
→ investigated in trials for	5-Aminolevulinic Acid 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Carcinoma In Situ	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Abemaciclibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Carcinoma In Situ	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Aldesleukinother 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Carcinoma In Situ	1	Observed	clinicaltrials	graph →

Carcinoma In Situ investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 32show all (up to 200)

→ investigated in trials for

Tamoxifensmall molecule

14 trials (6 active) · roll-up of the cancer and its descendants

—

Carcinoma In Situ

Observed

Carcinoma In Situ studied in …STUDIED_INderived10 of 274show all (up to 200)
→ studied in	NCT06833073Phase 2 · recruiting A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011) · condition mapped ONTOLOGY_EXACT · 274 trials mapped (92 active)	—	—	Carcinoma In Situ	1	Observed	clinicaltrials	graph →
→ studied in	NCT04570956Phase 2 · terminated Oral Tamoxifen vs. TamGel vs. Control in Women With Atypical Hyperplasia, Lobular Carcinoma In Situ, or Increased Breast Cancer Risk · condition mapped ONTOLOGY_EXACT · 274 trials mapped (92 active)	—	—	Breast Lobular Carcinoma In Situ	1	Observed	clinicaltrials	graph →
→ studied in	NCT07408856Phase 1 · recruiting CAN1012 in Pre-Malignant DCIS and LCIS · condition mapped ALIAS · 274 trials mapped (92 active)	—	—	Breast Lobular Carcinoma In Situ	1	Observed	clinicaltrials	graph →
→ studied in	NCT07711847NA · recruiting Personalized Prone Immobilization for Accelerated Partial Breast Radiotherapy · condition mapped ALIAS · 274 trials mapped (92 active)	—	—	Breast Ductal Carcinoma In Situ	1	Observed	clinicaltrials	graph →
→ studied in	NCT02620852NA · recruiting Women Informed to Screen Depending on Measures of Risk (Wisdom Study) · condition mapped ONTOLOGY_EXACT · 274 trials mapped (92 active)	—	—	Breast Carcinoma In Situ	1	Observed	clinicaltrials	graph →
→ studied in	NCT04084730Phase 2 · recruiting Study of 3-Day Partial Breast Radiation Therapy in Women With Breast Cancer · condition mapped ALIAS · 274 trials mapped (92 active)	—	—	Breast Ductal Carcinoma In Situ, Low Grade	1	Observed	clinicaltrials	graph →
→ studied in	NCT03077841Phase 2/Phase 3 · suspended Hypofractionated Partial Breast Irradiation in Treating Patients With Early Stage Breast Cancer · condition mapped ALIAS · 274 trials mapped (92 active)	—	—	Breast Ductal Carcinoma In Situ	1	Observed	clinicaltrials	graph →
→ studied in	NCT05014139Phase 1 · terminated A Study of Intravesical Enfortumab Vedotin For Treatment of Patients With Non-muscle Invasive Bladder Cancer (NMIBC) · condition mapped ONTOLOGY_EXACT · 274 trials mapped (92 active)	—	—	Carcinoma In Situ	1	Observed	clinicaltrials	graph →
→ studied in	NCT06033092Phase 2 · completed Low Dose TamOxifen and LifestylE Changes for bReast cANcer prevenTion · condition mapped ALIAS · 274 trials mapped (92 active)	—	—	Breast Lobular Carcinoma In Situ	1	Observed	clinicaltrials	graph →
→ studied in	NCT07764744NA · not yet recruiting Ovarian Cancer Liquid Biopsy for Early Assessment & Detection in Individuals With BRCA1/2 Pathogenic Variants · condition mapped ONTOLOGY_EXACT · 274 trials mapped (92 active)	—	—	Serous Tubal Intraepithelial Carcinoma	1	Observed	clinicaltrials	graph →

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